{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:46:36Z","timestamp":1791524796909,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["P20 NR008988"],"award-info":[{"award-number":["P20 NR008988"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["P30 NR011403"],"award-info":[{"award-number":["P30 NR011403"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["P20 NR008988"],"award-info":[{"award-number":["P20 NR008988"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["P30 NR011403"],"award-info":[{"award-number":["P30 NR011403"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Fibromyalgia (FMS) is a chronic pain syndrome with a complex but poorly understood pathogenesis affecting approximately 10 million adults in the United States. The lack of a clear etiology of FMS has limited the effective diagnosis and treatment of this debilitating condition. The objective of this secondary data analysis was to examine plasma cytokine levels in women with FMS using the Bio-Plex Human Cytokine 17-plex Assay. Post hoc analysis of plasma cytokine levels was performed to evaluate patterns that were not specified<jats:italic>a priori<\/jats:italic>. Upon examination, patients with FMS exhibited a marked reduction in<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:msub><mml:mrow><mml:mtext>T<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>H<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mn>2<\/mml:mn><\/mml:math>cytokines such as IL-4, IL-5, and IL-13. The finding of this pattern of altered cytokine milieu not only supports the role of inflammation in FMS but also may lead to more definitive diagnostic tools for clinicians treating FMS. The<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:msub><mml:mrow><mml:mtext>T<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>H<\/mml:mtext><\/mml:mrow><\/mml:msub><mml:mn>2<\/mml:mn><\/mml:math>suppression provides strong evidence of immune dysregulation in patients with FMS.<\/jats:p>","DOI":"10.1155\/2014\/938576","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T21:03:06Z","timestamp":1394571786000},"page":"1-5","source":"Crossref","is-referenced-by-count":49,"title":["Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia"],"prefix":"10.1155","volume":"2014","author":[{"given":"Jamie","family":"Sturgill","sequence":"first","affiliation":[{"name":"School of Nursing, Virginia Commonwealth University, Richmond, VA 23298, USA"},{"name":"Institute of Women\u2019s Health, Virginia Commonwealth University, Richmond, VA 23298, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"McGee","sequence":"additional","affiliation":[{"name":"Institute of Women\u2019s Health, Virginia Commonwealth University, Richmond, VA 23298, USA"},{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, VT 05401, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Menzies","sequence":"additional","affiliation":[{"name":"School of Nursing, Virginia Commonwealth University, Richmond, VA 23298, USA"},{"name":"Institute of Women\u2019s Health, Virginia Commonwealth University, Richmond, VA 23298, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"5","key":"2","first-page":"42","volume":"16","year":"2006","journal-title":"Clinician Reviews"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2174\/138161206775193208"},{"issue":"6","key":"4","first-page":"1415","volume":"34","year":"2007","journal-title":"Journal of Rheumatology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05032-11"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/art.22026"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1177\/1099800409348328"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-012-9464-7"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-245"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1159\/000341664"},{"issue":"7","key":"11","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","volume":"136","year":"1986","journal-title":"Journal of Immunology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2004.05.047"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3109\/08039488.2011.611894"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.08.013"},{"issue":"2","key":"15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/art.1780330203","volume":"33","year":"1990","journal-title":"Arthritis and Rheumatism"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100594"},{"key":"17","year":"1988"},{"key":"18","series-title":"Advances in Pain Research and Therapy","first-page":"391","volume-title":"Measurement of pain by subjective report","volume":"12","year":"1989"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990301)85:5&lt;1186::AID-CNCR24&gt;3.0.CO;2-N"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1828"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2011.10.013"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-7-96"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0311"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02924.x"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(03)00087-8"},{"issue":"3","key":"28","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/BF02828168","volume":"25","year":"2005","journal-title":"Journal of Huazhong University of Science and Technology: Medical Sciences"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3181\/0808-RM-254"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.3181\/0712-RM-328"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028205"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2013.02.005"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/938576.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/938576.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/938576.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T03:51:39Z","timestamp":1689047499000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2014\/938576\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":30,"alternative-id":["938576","938576"],"URL":"https:\/\/doi.org\/10.1155\/2014\/938576","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}