{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:31:58Z","timestamp":1792787518853,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"S\u00e3o Paulo Foundation Research"},{"name":"National Counsel of Technological and Scientific Development"},{"name":"Coordination for the Improvement of Higher Level Education Personnel"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"\n This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (\n GSTM1<\/jats:italic>\n ,\n GSTT1<\/jats:italic>\n ,\n GSTP1<\/jats:italic>\n ,\n GCLM<\/jats:italic>\n , and\n GCLC<\/jats:italic>\n ) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg). Subjects (\n \n n<\/mml:mi>\n =<\/mml:mo>\n 88<\/mml:mn>\n <\/mml:math>\n ), exposed to MeHg from fish consumption, were enrolled in the study. Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays. Mean total Hg levels in plasma (THgP) and whole blood (THgB) were\n \n 10<\/mml:mn>\n \u00b1<\/mml:mo>\n 4.2<\/mml:mn>\n <\/mml:math>\n and\n \n 37<\/mml:mn>\n \u00b1<\/mml:mo>\n 21<\/mml:mn>\n <\/mml:math>\n , whereas mean evels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP\/HgB were\n \n 4.3<\/mml:mn>\n \u00b1<\/mml:mo>\n 2.9<\/mml:mn>\n <\/mml:math>\n ,\n \n 5.8<\/mml:mn>\n \u00b1<\/mml:mo>\n 2.3<\/mml:mn>\n <\/mml:math>\n \u2009\u00b5g\/L, and\n \n 0.33<\/mml:mn>\n \u00b1<\/mml:mo>\n 0.15<\/mml:mn>\n <\/mml:math>\n , respectively.\n GSTM1<\/jats:italic>\n and\n GCLC<\/jats:italic>\n polymorphisms influence THgP and MeHgP (multivariate analyses,\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.050<\/mml:mn>\n <\/mml:math>\n ). Null homozygotes for\n GSTM1<\/jats:italic>\n showed higher THgP and MeHgP levels compared to subjects with\n GSTM1<\/jats:italic>\n (THgP\n \n \u03b2<\/mml:mi>\n =<\/mml:mo>\n 0.22<\/mml:mn>\n <\/mml:math>\n ,\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.035<\/mml:mn>\n <\/mml:math>\n ; MeHgP\n \n \u03b2<\/mml:mi>\n =<\/mml:mo>\n 0.30<\/mml:mn>\n <\/mml:math>\n ,\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.050<\/mml:mn>\n <\/mml:math>\n ) and persons carrying at least one T allele for\n GCLC<\/jats:italic>\n had significant higher MeHgP (\n \n \u03b2<\/mml:mi>\n =<\/mml:mo>\n 0.59<\/mml:mn>\n <\/mml:math>\n ,\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.046<\/mml:mn>\n <\/mml:math>\n ). Also, polymorphic\n GCLM<\/jats:italic>\n subjects had lower THgP\/THgB than those with the nonvariant genotype. Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP\/HgB partitioning.\n <\/jats:p>","DOI":"10.1155\/2014\/940952","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T16:04:50Z","timestamp":1392739490000},"page":"1-8","source":"Crossref","is-referenced-by-count":19,"title":["Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg\/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population"],"prefix":"10.1155","volume":"2014","author":[{"given":"Andr\u00e9ia \u00c1vila Soares","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Avenida do Caf\u00e9 s\/n\u00b0, 14040-903 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilesia Ferreira de","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of General Biology, Center for Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid km 380, 86051-990 Londrina, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 van Helvoort","family":"Lengert","sequence":"additional","affiliation":[{"name":"Department of General Biology, Center for Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid km 380, 86051-990 Londrina, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Tempesta","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of General Biology, Center for Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid km 380, 86051-990 Londrina, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana Batista de Oliveira Godoy","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of General Biology, Center for Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid km 380, 86051-990 Londrina, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto \u00dabida Leite","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Avenida do Caf\u00e9 s\/n\u00b0, 14040-903 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilce Mara de Syllos","family":"C\u00f3lus","sequence":"additional","affiliation":[{"name":"Department of General Biology, Center for Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid km 380, 86051-990 Londrina, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Avenida do Caf\u00e9 s\/n\u00b0, 14040-903 Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Rafael Mazzaron","family":"Barcelos","sequence":"additional","affiliation":[{"name":"Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Avenida do Caf\u00e9 s\/n\u00b0, 14040-903 Ribeir\u00e3o Preto, SP, 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