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For the<jats:italic>in vitro<\/jats:italic>experiment, four pairs of adult worms, obtained from infected mice, were exposed to different concentrations of MFM (100 to 400\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) for 24 and 48\u2009h and analyzed under an inverted microscope. For the<jats:italic>in vivo<\/jats:italic>experiment, mice were inoculated with cercariae and, 20 days after infection, MFM (100 and 300\u2009mg\/kg) was administered orally for the following 25 days. Mice were euthanized after 60 days. MFM showed<jats:italic>in vitro<\/jats:italic>schistosomicidal activity, exhibiting the opening of the gynaecophoral canal of some male schistosomes, the presence of contorted muscles, vesicles, and the darkening of the paired worms skin.<jats:italic>In vivo<\/jats:italic>experiments showed that MFM treatments significantly reduced total worm count, as praziquantel, showing a decrease in liver and spleen weight. Also, a significant reduction in granuloma density was observed. MFM treatment did not cause alterations in the liver function of either infected or noninfected mice. The HPLC chromatogram profile showed the presence of kaempferol-<jats:italic>O<\/jats:italic>-rutinoside, rutin, kaempferol, psychorubrin, and ursolic acid.<\/jats:p>","DOI":"10.1155\/2014\/941318","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T21:23:26Z","timestamp":1399584206000},"page":"1-10","source":"Crossref","is-referenced-by-count":17,"title":["Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant Species<i>Mitracarpus frigidus<\/i>on Adult<i>Schistosoma mansoni<\/i>Worms"],"prefix":"10.1155","volume":"2014","author":[{"given":"Rodrigo Luiz","family":"Fabri","sequence":"first","affiliation":[{"name":"Bioactive Natural Products Laboratory, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, 36036 900 Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Maria de 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