{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:39:16Z","timestamp":1762101556256,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Koshiyama Research Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Oxidative stress is considered to be a mechanism of major depression. Pycnogenol (PYC) is a natural plant extract from the bark of<jats:italic>Pinus pinaster<\/jats:italic>Aiton and has potent antioxidant activities. We studied the ameliorative effect of PYC on depression-like behavior in chronic corticosterone- (CORT-) treated mice for 20 days. After the end of the CORT treatment period, PYC (0.2\u2009mg\/mL) was orally administered in normal drinking water. Depression-like behavior was investigated by the forced swimming test. Immobility time was significantly longer by CORT exposure. When the CORT-treated mice were supplemented with PYC, immobility time was significantly shortened. Our results indicate that orally administered PYC may serve to reduce CORT-induced stress by radical scavenging activity.<\/jats:p>","DOI":"10.1155\/2014\/942927","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T17:22:23Z","timestamp":1400001743000},"page":"1-4","source":"Crossref","is-referenced-by-count":10,"title":["Pycnogenol Ameliorates Depression-Like Behavior in Repeated Corticosterone-Induced Depression Mice Model"],"prefix":"10.1155","volume":"2014","author":[{"given":"Lin","family":"Mei","sequence":"first","affiliation":[{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyako","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Kyoto Bunkyo Junior College, 80 Senzoku, Makishima-cho, Uji, Kyoto 611-0041, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3347-0311","authenticated-orcid":true,"given":"Noboru","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Health and Medical Sciences, Ishikawa Prefectural Nursing University, 1-1 Gakuendai, Kahoku, Ishikawa 929-1210, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00199-3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.3.5.13109"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1080\/10253890701292119"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301574"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/10253890802234168"},{"key":"6","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1590\/1516-4446-2013-1098","volume":"35","year":"2013","journal-title":"Revista Brasileira de Psiquiatria"},{"year":"2010","key":"7"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.07.016"},{"issue":"3, supplement","key":"9","first-page":"65","volume":"53","year":"2011","journal-title":"Panminerva Medica"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.10-58"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03907.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10311"},{"issue":"2","key":"13","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3904\/kjim.2013.28.2.216","volume":"28","year":"2013","journal-title":"Korean Journal of Internal Medicine"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/942927.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/942927.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/942927.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T09:08:54Z","timestamp":1498122534000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/942927\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":13,"alternative-id":["942927","942927"],"URL":"https:\/\/doi.org\/10.1155\/2014\/942927","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2014]]}}}