{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:58:13Z","timestamp":1775894293460,"version":"3.50.1"},"reference-count":15,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>Sugammadex offers a good alternative to the conventional decurarisation process currently performed with cholinesterase inhibitors. Sugammadex, which was developed specifically for the aminosteroid-structured rocuronium and vecuronium neuromuscular blockers, is a modified cyclodextrin made up of 8 glucose monomers arranged in a cylindrical shape.<jats:italic>Methods.<\/jats:italic>In this study, the goal was to investigate the efficacy of sugammadex. Sugammadex was used when there was insufficient decurarisation following neostigmine. This study was performed on 14 patients who experienced insufficient decurarisation (TOF<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo>&lt;<\/mml:mo><mml:mn>0.9<\/mml:mn><\/mml:math>) with neostigmine after general anaesthesia in the operating rooms of a university and a state hospital between June, 2012, and January, 2014. A dose of 2\u2009mg\/kg of sugammadex was administered.<jats:italic>Results.<\/jats:italic>Time elapsed until sugammadex administration following neostigmine<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>37<\/mml:mn><mml:mi mathvariant=\"normal\">\u00a0<\/mml:mi><mml:mo>\u00b1<\/mml:mo><mml:mi mathvariant=\"normal\">\u00a0<\/mml:mi><mml:mn>6<\/mml:mn><\/mml:math>min, following sugammadex it took<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn>2.1<\/mml:mn><mml:mi mathvariant=\"normal\">\u00a0<\/mml:mi><mml:mo>\u00b1<\/mml:mo><mml:mi mathvariant=\"normal\">\u00a0<\/mml:mi><mml:mn>0.9<\/mml:mn><\/mml:math>min to reach TOF<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mo>\u2265<\/mml:mo><mml:mi>\u00a0<\/mml:mi><mml:mn>0.9<\/mml:mn><\/mml:math>, and the extubation time was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn>3.2<\/mml:mn><mml:mi mathvariant=\"normal\">\u00a0<\/mml:mi><mml:mo>\u00b1<\/mml:mo><mml:mi mathvariant=\"normal\">\u00a0<\/mml:mi><mml:mn>1.4<\/mml:mn><\/mml:math>min. No statistically significant differences were detected in the hemodynamic parameters before and after sugammadex application. From the time of administration of sugammadex to the second postoperative hour, no side effects or complications occurred. None of the patients experienced acute respiratory failure or residual block during this time period.<jats:italic>Conclusion.<\/jats:italic>Sugammadex was successfully used to reverse rocuronium-induced neuromuscular block in patients where neostigmine was insufficient.<\/jats:p>","DOI":"10.1155\/2014\/945310","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T22:15:54Z","timestamp":1408054554000},"page":"1-4","source":"Crossref","is-referenced-by-count":8,"title":["A Miracle That Accelerates Operating Room Functionality: Sugammadex"],"prefix":"10.1155","volume":"2014","author":[{"given":"Erdal","family":"Dogan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Faculty of Medicine, Dicle University Medical School, Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Salim","family":"Akdemir","sequence":"additional","affiliation":[{"name":"The Education and \u0130nvestigation Hospital of Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmenap","family":"Guzel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Faculty of Medicine, Dicle University Medical School, Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Besir","family":"Yildirim","sequence":"additional","affiliation":[{"name":"The Pediatrics Hospital of Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Baysal Yildirim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Faculty of Medicine, Dicle University Medical School, Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahir","family":"Kuyumcu","sequence":"additional","affiliation":[{"name":"The Education and \u0130nvestigation Hospital of Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdurrahman","family":"G\u00fcm\u00fc\u015f","sequence":"additional","affiliation":[{"name":"Tatvan State Hospital, Bitlis, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Akelma","sequence":"additional","affiliation":[{"name":"The Education and \u0130nvestigation Hospital of Diyarbakir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","first-page":"151","volume-title":"Neuromuscular transmission and muscle relaxants","volume":"3rd","year":"2007"},{"key":"2","first-page":"179","volume-title":"Neuromuscular blocking agent","year":"2010"},{"issue":"2","key":"3","first-page":"61","volume":"4","year":"2011","journal-title":"Turkiye Klinikleri Journal Anesthesiology and 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