{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:41:37Z","timestamp":1753886497144,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T00:00:00Z","timestamp":1407801600000},"content-version":"vor","delay-in-days":223,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Austrian Federal Ministries of Science, Research, and Economy"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>We observed the inhibitive effect of electroacupuncture (EA) at Zusanli on inflammatory mediators of postoperative intra\u2010abdominal adhesions to find out the relationship between EA and the cholinergic anti\u2010inflammatory pathway. Sixty\u2010four rats were divided into 8 groups (A\u2013H, each = 8): A = sham control; B = abdominal adhesions model; C = abdominal adhesions plus EA; D = sham acupoint control; E = abdominal adhesions plus vagotomy; F = abdominal adhesions plus EA after vagotomy; G = abdominal adhesions plus <jats:italic>\u03b1<\/jats:italic>\u2010bungarotoxin (BGT); and H = abdominal adhesions plus EA after <jats:italic>\u03b1<\/jats:italic>\u2010BGT. <jats:italic>\u03b1<\/jats:italic>\u2010BGT (1\u2009<jats:italic>\u03bc<\/jats:italic>g\/kg) was injected into the abdominal cavity after surgery, and the bilateral celiac vagotomy was done during the surgery. On the third day the levels of inflammatory mediators (TNF\u2010<jats:italic>\u03b1<\/jats:italic>, nitric oxide (NO), and nitric oxide synthase (NOS)) in tissues were evaluated. The abdominal adhesion groups developed obvious edema. Compared with sham control, the abdominal adhesion resulted in a significant elevation of inflammatory mediators. EA lowered the elevated levels of inflammatory mediators significantly; EA plus <jats:italic>\u03b1<\/jats:italic>\u2010BGT and vagotomy showed less anti\u2010inflammatory effects. The activation of the cholinergic anti\u2010inflammatory pathway might be one of the mechanisms of EA at Zusanli acupoints to exert the anti\u2010inflammatory effects.<\/jats:p>","DOI":"10.1155\/2014\/950326","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T21:19:52Z","timestamp":1407878392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Inhibiting Effect of Electroacupuncture at Zusanli on Early Inflammatory Factor Levels Formed by Postoperative Abdominal Adhesions"],"prefix":"10.1155","volume":"2014","author":[{"given":"Lijian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huizhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenjun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9496-2213","authenticated-orcid":false,"given":"Ingrid","family":"Gaischek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-3521","authenticated-orcid":false,"given":"Daniela","family":"Litscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-7108","authenticated-orcid":false,"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-0130","authenticated-orcid":false,"given":"Gerhard","family":"Litscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,12]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082389"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000050149"},{"key":"e_1_2_7_3_2","first-page":"377","article-title":"The protective effects of electro-acunpunture at Zusanli point on proinflammatory factors induced- myocardial injury in septic rats","volume":"31","author":"Zhang L. 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