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The mean size of the core-shell quantum dots (28\u2009nm), as determined by dynamic light scattering, increased to 86\u2009nm after herceptin immobilization. The<jats:italic>in vitro<\/jats:italic>cell culture experiment showed that the keratin forming cancer cells (KB) proliferated well in the presence of herceptin-conjugated QDs (QD-Her, 5\u2009nmol\/mL), whereas most of the breast cancer cells (SK-BR3) had died. To clarify the mechanism of cell death, the interaction of SK-BR3 cells with QD-Her was examined by confocal laser scanning microscopy. As a result, the QD-Her bound specifically to the membrane of SK-BR3, which became almost saturated after 6 hours incubation. This suggests that the growth signal of breast cancer cells is inhibited completely by the specific binding of herceptin to the Her-2 receptor of SK-BR3 membrane, resulting in cell death.<\/jats:p>","DOI":"10.1155\/2014\/954307","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T16:05:34Z","timestamp":1389283534000},"page":"1-9","source":"Crossref","is-referenced-by-count":12,"title":["Specific Intracellular Uptake of Herceptin-Conjugated CdSe\/ZnS Quantum Dots into Breast Cancer Cells"],"prefix":"10.1155","volume":"2014","author":[{"given":"Seung-Jin","family":"Han","sequence":"first","affiliation":[{"name":"School of Applied Chemical Engineering, Kyungpook National University, Daegu 702-701, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierson","family":"Rathinaraj","sequence":"additional","affiliation":[{"name":"School of Applied Chemical Engineering, Kyungpook National University, Daegu 702-701, Republic of 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