{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T23:42:40Z","timestamp":1724715760689},"reference-count":37,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Urology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. New therapies evolve for the treatment of Peyronie's disease (PD) including the application of dexamethasone and verapamil using Electro Motive Drug Administration (EMDA).<jats:italic>Patients and Methods<\/jats:italic>. Patients with PD were routinely offered Potaba, Vitamin E, tamoxifen or colchicine for 6 to 18 months and for those with no improvement, 18 applications of dexamethasone and verapamil using EMDA occurred over a 6 week period. All 30 patients receiving EMDA therapy completed a questionnaire before and after treatment. The data was collected from December 2004 to November 2009 and analysed to evaluate the effectiveness of the treatment.<jats:italic>Results<\/jats:italic>. Median age of patients was 59 (range 39\u201371). Curvature was the most common presenting complaint (73.3%) followed by pain (23.3%), erectile dysfunction (13.3%), and lump (13.3%). 24\/30 (80%) reported an improvement in symptoms after EMDA. 16 of the responders (66.7%) had a stable plaque for at least 6 months. The patients who complained of shortening of the penis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>) or lowered sexual desire (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.024<\/mml:mn><\/mml:math>) expressed subsequently significant response to treatment. There was statistically significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.019<\/mml:mn><\/mml:math>) improvement of penile deviation reported by responding men.<jats:italic>Conclusion<\/jats:italic>. A significant proportion of patients who received EMDA reported decreased curvature following iontophoresis. No serious adverse reactions developed.<\/jats:p>","DOI":"10.1155\/2014\/957013","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T21:10:51Z","timestamp":1396559451000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Structured Self-Rated Response to Iontophoresis with Verapamil and Dexamethasone in Peyronie\u2019s Disease"],"prefix":"10.1155","volume":"2014","author":[{"given":"Abas","family":"Kokab","sequence":"first","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevan","family":"Wylie","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK"},{"name":"Sheffield Health and Social Care NHS Foundation Trust, Sheffield S11 9BF, 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