{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:12:14Z","timestamp":1774365134901,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Rede Instituto Brasileiro de Neuroci\u00eancia","award":["01.06.0842-00"],"award-info":[{"award-number":["01.06.0842-00"]}]},{"name":"Rede Instituto Brasileiro de Neuroci\u00eancia","award":["473365\/2009-0"],"award-info":[{"award-number":["473365\/2009-0"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["01.06.0842-00"],"award-info":[{"award-number":["01.06.0842-00"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["473365\/2009-0"],"award-info":[{"award-number":["473365\/2009-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>In this study, we investigated the possible antidepressant-like effect of<jats:italic>I. paraguariensis<\/jats:italic>in rats. Rats were treated for four weeks with an aqueous extract of<jats:italic>I. paraguariensis<\/jats:italic>in drinking water, following the traditional preparation of this beverage. After the period of treatment, behavioral (elevated plus-maze, open field test, and forced swimming test) and biochemical parameters (lipid peroxidation assay, thiol content, vitamin C levels, and monoamine oxidase activity) were evaluated. Animals were also analyzed on forced swimming test after 24 hours of<jats:italic>I. paraguariensis<\/jats:italic>intake. An additional group was injected with selegiline 24 hours and 30 minutes before forced swimming test as positive control. HPLC analysis revealed the profile of<jats:italic>I. paraguariensis<\/jats:italic>extract.<jats:italic>I. paraguariensis<\/jats:italic>reduced the immobility time on forced swimming test without significant changes in locomotor activity in the open field test. Any anxiolytic\/anxiogenic effect of<jats:italic>I. paraguariensis<\/jats:italic>was observed in rats through the elevated plus-maze test. The antidepressant-like effect of<jats:italic>I. paraguariensis<\/jats:italic>was not accompanied by inhibitory effect on monoamine oxidase activity. There were no significant alterations on lipid peroxidation, thiol content, and vitamin C levels among the groups. In conclusion, aqueous extract of<jats:italic>I. paraguariensis<\/jats:italic>decreases the time of immobility in rats suggesting an antidepressant-like effect.<\/jats:p>","DOI":"10.1155\/2014\/958209","type":"journal-article","created":{"date-parts":[[2014,5,4]],"date-time":"2014-05-04T21:09:39Z","timestamp":1399237779000},"page":"1-9","source":"Crossref","is-referenced-by-count":22,"title":["Antidepressant-Like Effect of<i>Ilex paraguariensis<\/i>in Rats"],"prefix":"10.1155","volume":"2014","author":[{"given":"Elizete De Moraes","family":"Reis","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farmacologia, 97105-900 Santa Maria, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Waldomiro Schreiner","family":"Neto","sequence":"additional","affiliation":[{"name":"Curso de Farm\u00e1cia, Universidade de Cruz Alta, 98020-290 Cruz Alta, RS, 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