{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:15:23Z","timestamp":1780449323958,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"vor","delay-in-days":105,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102507"],"award-info":[{"award-number":["81102507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Bavachalcone and corylin are two major bioactive compounds isolated from <jats:italic>Psoralea corylifolia<\/jats:italic> L., which has been widely used as traditional Chinese medicine for many years. As two antibiotic or anticancer drugs, bavachalcone and corylin are used in combination with other drugs; thus it is necessary to evaluate potential pharmacokinetic herb\u2010drug interactions (HDI) of the two bioactive compounds. The aim of the present study was to compare the effects of liver UDP\u2010glucuronosyltransferase (UGT) 1A1, UGT1A3, UGT1A7, UGT1A8, UGT 1A10, and UGT2B4 inhibited by bavachalcone and corylin. 4\u2010Methylumbelliferone (4\u2010MU) was used as a nonspecific \u201cprobe\u201d substrate. Bavachalcone had stronger inhibition on UGT1A1 and UGT1A7 than corylin which did not inhibit UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A10, and UGT2B4. Data fitting using Dixon and Lineweaver\u2010Burk plots demonstrated the noncompetitive inhibition of bavachalcone against UGT1A1 and UGT1A7\u2010mediated 4\u2010MU glucuronidation reaction. The values of inhibition kinetic parameters (Ki) were 5.41\u2009<jats:italic>\u03bc<\/jats:italic>M and 4.51\u2009<jats:italic>\u03bc<\/jats:italic>M for UGT1A1 and UGT1A7, respectively. The results of present study suggested that there was a possibility of UGT1A1 and UGT1A7 inhibition\u2010based herb\u2010drug interaction associated with bavachalcone and provided the basis for further in vivo studies to investigate the HDI potential between bavachalcone and UGT substrates.<\/jats:p>","DOI":"10.1155\/2014\/958937","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T21:13:49Z","timestamp":1397682829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP\u2010Glucuronosyltransferases"],"prefix":"10.1155","volume":"2014","author":[{"given":"Lina","family":"Shan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9638-0890","authenticated-orcid":false,"given":"Shuman","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianbao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,16]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-009-1118-8"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200600339"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.04.093"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.11.001"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(99)00151-3"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.05.083"},{"key":"e_1_2_7_7_2","first-page":"473","article-title":"Electron microscopical observation on rats with Pneumocystis carinii pneumonia treated with Brucea javanica and Fructus psoraleae","volume":"24","author":"Ren Y. 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