{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:51:50Z","timestamp":1762375910123,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Sodium meta-arsenite (SA) is implicated in the regulation of hepatic gluconeogenesis-related genes<jats:italic>in vitro<\/jats:italic>; however, the effects<jats:italic>in vivo<\/jats:italic>have not been studied. We investigated whether SA has antidiabetic effects in a type 2 diabetic mouse model. Diabetic<jats:italic>db\/db<\/jats:italic>mice were orally intubated with SA (10\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>body weight\/day) for 8 weeks. We examined hemoglobin A1c (HbA1c), blood glucose levels, food intake, and body weight. We performed glucose, insulin, and pyruvate tolerance tests and analyzed glucose production and the expression of gluconeogenesis-related genes in hepatocytes. We analyzed energy metabolism using a comprehensive animal metabolic monitoring system. SA-treated diabetic<jats:italic>db\/db<\/jats:italic>mice had reduced concentrations of HbA1c and blood glucose levels. Exogenous glucose was quickly cleared in glucose tolerance tests. The mRNA expressions of genes for gluconeogenesis-related enzymes, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly reduced in the liver of SA-treated diabetic<jats:italic>db\/db<\/jats:italic>mice. In primary hepatocytes, SA treatment decreased glucose production and the expression of G6Pase, PEPCK, and hepatocyte nuclear factor 4 alpha (HNF-4<jats:italic>\u03b1<\/jats:italic>) mRNA. Small heterodimer partner (SHP) mRNA expression was increased in hepatocytes dependent upon the SA concentration. The expression of Sirt1 mRNA and protein was reduced, and acetylated forkhead box protein O1 (FoxO1) was induced by SA treatment in hepatocytes. In addition, SA-treated diabetic<jats:italic>db\/db<\/jats:italic>mice showed reduced energy expenditure. Oral intubation of SA ameliorates hyperglycemia in<jats:italic>db\/db<\/jats:italic>mice by reducing hepatic gluconeogenesis through the decrease of Sirt1 expression and increase in acetylated FoxO1.<\/jats:p>","DOI":"10.1155\/2014\/961732","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T16:06:14Z","timestamp":1419437174000},"page":"1-11","source":"Crossref","is-referenced-by-count":9,"title":["Sodium Meta-Arsenite Ameliorates Hyperglycemia in Obese Diabetic<i>db\/db<\/i>Mice by Inhibition of Hepatic Gluconeogenesis"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-6093","authenticated-orcid":true,"given":"Young-Sun","family":"Lee","sequence":"first","affiliation":[{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 7-45 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Kyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 7-45 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Hee","family":"Oh","sequence":"additional","affiliation":[{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 7-45 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol Soo","family":"Choi","sequence":"additional","affiliation":[{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 7-45 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea"},{"name":"Endocrinology, Internal Medicine, Gachon University Gil Medical Center, Namdong-gu, Guwol-dong 1198, Incheon 405-760, Republic of Korea"},{"name":"Gachon Medical Research Institute, Gil Hospital, Incheon 405-760, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujong","family":"Kim","sequence":"additional","affiliation":[{"name":"Komipharm International Co. Ltd., 3188 Seongnam-dong, Jungwon-gu, Seongnam-si, Gyeonggi-do 462-827, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Sook","family":"Jun","sequence":"additional","affiliation":[{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 7-45 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea"},{"name":"Gachon Medical Research Institute, Gil Hospital, Incheon 405-760, Republic of Korea"},{"name":"College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, 7-45 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4266(04)95627-2"},{"issue":"2","key":"2","first-page":"200","volume":"57","year":"2011","journal-title":"Postepy Biochemii"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2741\/3301"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-013-0018-5"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.19.1.379"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100589"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1172\/jci115997"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2011.76.010942"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-010-0052-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1996.0016"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00224-4"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403021"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/nrc887"},{"issue":"3","key":"14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1289\/ehp.01109245","volume":"109","year":"2001","journal-title":"Environmental Health Perspectives"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00800.2007"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.6.896"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.2307\/3434145"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.06.010"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3109\/10799893.2012.660531"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0211"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m314322200"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1172\/jci200112876"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502738102"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m113.504845"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.02.006"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2007.06.004"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.23.14398"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.10.005"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00401-X"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2008.09.021"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.06.007"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1894"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801613105"},{"issue":"1","key":"34","first-page":"162","volume":"172","year":"1953","journal-title":"American Journal of Physiology"},{"issue":"4","key":"35","first-page":"124","volume":"41","year":"1983","journal-title":"Nutrition Reviews"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.003"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.5.593"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5335.135"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802253"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/nm1392"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00094.2005"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.245"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2014\/961732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2014\/961732.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2014\/961732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T22:40:59Z","timestamp":1498171259000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jdr\/2014\/961732\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":42,"alternative-id":["961732","961732"],"URL":"https:\/\/doi.org\/10.1155\/2014\/961732","relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"type":"print","value":"2314-6745"},{"type":"electronic","value":"2314-6753"}],"subject":[],"published":{"date-parts":[[2014]]}}}