{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:29:10Z","timestamp":1761863350291,"version":"3.37.3"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid synthesized by animals, but not by humans or birds. However, it can be incorporated in human cells and can trigger immune response. In the present study, we detected anti-Neu5Gc antibodies in samples of the general population and of patients suffering from hypothyroidism\/Hashimoto\u2019s disease, which is known to have autoimmune origin.<jats:italic>Methods<\/jats:italic>. Antibodies were measured using enzyme-immunosorbent techniques.<jats:italic>Results<\/jats:italic>. Serum anti-Neu5Gc IgG antibodies were higher in patients with hypothyroidism (mean:\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>14.8<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>15.9<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, median:\u200910.0\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0003<\/mml:mn><\/mml:math>, Mann-Whitney) and even higher in the group with Hashimoto\u2019s thyroiditis (mean:\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn>31.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>16.3<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, median:\u200927.2\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi mathvariant=\"normal\">P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0000<\/mml:mn><\/mml:math>, Mann-Whitney) compared to the general population (mean:\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn>5.3<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>4.7<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, median\u2009:\u20094\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL). All anti-TPO positive samples had anti-Neu5Gc antibody concentration higher than the mean value of the general population while anti-TPO concentration was increased as anti-Neu5Gc concentration increased. Low concentrations of IgA and IgM antibodies were measured in both general population and patient groups.<jats:italic>Conclusion<\/jats:italic>. The increased values of anti-Neu5Gc antibodies in patients with hypothyroidism\/Hashimoto\u2019s disease and the correlation of anti-TPO incidence with increased anti-Neu5Gc concentration raise the possibility of an association between anti-Neu5Gc antibody development and autoimmune hypothyroidism.<\/jats:p>","DOI":"10.1155\/2014\/963230","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T21:26:13Z","timestamp":1402349173000},"page":"1-9","source":"Crossref","is-referenced-by-count":15,"title":["Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8376-752X","authenticated-orcid":true,"given":"Phaedra","family":"Eleftheriou","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Studies, School of Health and Medical Care, Alexander Technological Educational Institute of Thessaloniki, TEI Campus Sindos, 57400 Thessaloniki, 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Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2053-4651","authenticated-orcid":true,"given":"John","family":"Yovos","sequence":"additional","affiliation":[{"name":"1st Internal Medicine Department, AHEPA University General Hospital of Thessaloniki, St. Kyriakidi 1, 54636 Thessaloniki, Greece"},{"name":"Aristotle University of Thessaloniki, St. Kyriakidi 1, 54636 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros","family":"Skepastianos","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Studies, School of Health and Medical Care, Alexander Technological Educational Institute of Thessaloniki, TEI Campus Sindos, 57400 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Vagdatli","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Studies, School of Health and Medical Care, Alexander 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