{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T14:47:27Z","timestamp":1746456447685,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. YKL-40 association with human disease has been the object of many years of investigation.<jats:italic>\u03b2<\/jats:italic>-thalassemia patients are affected by hepatic siderosis, which determines a fibrotic process and tissue remodelling. Chitotriosidase has been found to be increased in thalassemic patients returning to normal in patients submitted to bone marrow transplantation. YKL-40 is associated with macrophage activation in liver and in other tissues. The aim of the study was to analyse the level of serum YKL-40 and plasma chitotriosidase activity of patients with beta-thalassemia to assess whether their expression correlates with liver disease and degree of liver siderosis.<jats:italic>Methods<\/jats:italic>. Expression of YKL-40 and chitotriosidase as a marker of inflammation in 69 thalassemic patients were evaluated. We sought to investigate whether these two chitinases could be considered as a significant biomarker to evaluate therapy effectiveness.<jats:italic>Results<\/jats:italic>. Surprisingly we found normal value of YKL-40. We, also, analysed chitotriosidase activity in the same patients that was slightly increased as a consequence of macrophage activation.<jats:italic>Conclusions<\/jats:italic>. These data would suggest a good treatment for these patients.<\/jats:p>","DOI":"10.1155\/2014\/965971","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T17:54:54Z","timestamp":1396979694000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Serum YKL-40 Levels and Chitotriosidase Activity in Patients with Beta-Thalassemia Major"],"prefix":"10.1155","volume":"2014","author":[{"given":"Maria","family":"Musumeci","sequence":"first","affiliation":[{"name":"Center for Integrated Research, Department of Laboratory Medicine and Microbiology, Campus Bio-Medico University of Rome, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Caruso","sequence":"additional","affiliation":[{"name":"Center of Microcitemia, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Medulla","sequence":"additional","affiliation":[{"name":"Center of 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