{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:15:11Z","timestamp":1784304911234,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Multan Institute of Nuclear Medicine and Radiotherapy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"Naja naja karachiensis<\/jats:italic>envenomation was found to hit more drastically heart, liver, and kidneys. 400\u2009\u03bc<\/jats:italic>g\/kg of venom-raised moderate serum levels of ALT (72<\/mml:mn>\u00b1<\/mml:mo>4.70<\/mml:mn><\/mml:math>\u2009U\/L,0.1<\/mml:mn>><\/mml:mo>P<\/mml:mi>><\/mml:mo>0.05<\/mml:mn><\/mml:math>), AST (157<\/mml:mn>\u00b1<\/mml:mo>24.24<\/mml:mn><\/mml:math>\u2009U\/L,0.1<\/mml:mn>><\/mml:mo>P<\/mml:mi>><\/mml:mo>0.05<\/mml:mn><\/mml:math>), urea (42<\/mml:mn>\u00b1<\/mml:mo>3.08<\/mml:mn><\/mml:math>\u2009mg\/dL,0.05<\/mml:mn>><\/mml:mo>P<\/mml:mi>><\/mml:mo>0.02<\/mml:mn><\/mml:math>), creatinine (1.74<\/mml:mn>\u00b1<\/mml:mo>0.03<\/mml:mn><\/mml:math>\u2009mg\/dL,0.01<\/mml:mn>><\/mml:mo>P<\/mml:mi>><\/mml:mo>0.001<\/mml:mn><\/mml:math>), CK-MB (21<\/mml:mn>\u00b1<\/mml:mo>1.5<\/mml:mn><\/mml:math>\u2009U\/L,0.05<\/mml:mn>><\/mml:mo>P<\/mml:mi>><\/mml:mo>0.02<\/mml:mn><\/mml:math>), and LDH (2064<\/mml:mn>\u00b1<\/mml:mo>15.98<\/mml:mn><\/mml:math>\u2009U\/L,P<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:math>) were injected in experimental rabbits. However, lethality was enhanced with 800\u2009\u03bc<\/jats:italic>g\/kg of venom in terms of significant release of ALT (86<\/mml:mn>\u00b1<\/mml:mo>5.0<\/mml:mn><\/mml:math>\u2009U\/L,0.05<\/mml:mn>><\/mml:mo>P<\/mml:mi>><\/mml:mo>0.02<\/mml:mn><\/mml:math>), AST (251<\/mml:mn>\u00b1<\/mml:mo>18.2<\/mml:mn><\/mml:math>\u2009U\/L,0.01<\/mml:mn>><\/mml:mo>P<\/mml:mi>><\/mml:mo>0.001<\/mml:mn><\/mml:math>), urea (57.6<\/mml:mn>\u00b1<\/mml:mo>3.84<\/mml:mn><\/mml:math>\u2009mg\/dL,0.02<\/mml:mn>><\/mml:mo>P<\/mml:mi>><\/mml:mo>0.01<\/mml:mn><\/mml:math>), creatinine (2.1<\/mml:mn>\u00b1<\/mml:mo>0.10<\/mml:mn><\/mml:math>\u2009mg\/dL,0.02<\/mml:mn>><\/mml:mo>P<\/mml:mi>><\/mml:mo>0.01<\/mml:mn><\/mml:math>), CK-MB (77<\/mml:mn>\u00b1<\/mml:mo>11.22<\/mml:mn><\/mml:math>\u2009U\/L,0.05<\/mml:mn>><\/mml:mo>P<\/mml:mi>><\/mml:mo>0.02<\/mml:mn><\/mml:math>), and LDH (2562<\/mml:mn>\u00b1<\/mml:mo>25.14<\/mml:mn><\/mml:math>\u2009U\/L,P<\/mml:mi>\u226a<\/mml:mo>0.001<\/mml:mn><\/mml:math>). Among twenty-eight tested medicinal plant extracts, onlyStenolobium stans<\/jats:italic>(L.) Seem was found the best antivenom (P<\/mml:mi>><\/mml:mo>0.5<\/mml:mn><\/mml:math>) compared to the efficacy of standard antidote (ALT=<\/mml:mo>52.5<\/mml:mn>\u00b1<\/mml:mo>3.51<\/mml:mn><\/mml:math>\u2009U\/L, AST=<\/mml:mo>69.5<\/mml:mn>\u00b1<\/mml:mo>18.55<\/mml:mn><\/mml:math>\u2009U\/L, urea=<\/mml:mo>31.5<\/mml:mn>\u00b1<\/mml:mo>0.50<\/mml:mn><\/mml:math>\u2009mg\/dL, creatinine=<\/mml:mo>1.08<\/mml:mn>\u00b1<\/mml:mo>0.02<\/mml:mn><\/mml:math>\u2009mg\/dL, CK-MB=<\/mml:mo>09<\/mml:mn>\u00b1<\/mml:mo>0.85<\/mml:mn><\/mml:math>\u2009U\/L, and LDH=<\/mml:mo>763<\/mml:mn>\u00b1<\/mml:mo>6.01<\/mml:mn><\/mml:math>\u2009U\/L). Other plant extracts were proved less beneficial and partly neutralized the toxicities posed by cobra venom. However, it is essential in future to isolate and characterize bioactive compound(s) fromStenolobium stans<\/jats:italic>(L.) Seem extract to overcome the complications of snake bite.<\/jats:p>","DOI":"10.1155\/2014\/970540","type":"journal-article","created":{"date-parts":[[2014,4,27]],"date-time":"2014-04-27T21:05:04Z","timestamp":1398632704000},"page":"1-13","source":"Crossref","is-referenced-by-count":10,"title":["Naja naja karachiensis<\/i>Envenomation: Biochemical Parameters for Cardiac, Liver, and Renal Damage along with Their Neutralization by Medicinal Plants"],"prefix":"10.1155","volume":"2014","author":[{"given":"Muhammad Hassham Hassan Bin","family":"Asad","sequence":"first","affiliation":[{"name":"Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5649-5768","authenticated-orcid":true,"given":"Ghulam","family":"Murtaza","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, 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