{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:33:45Z","timestamp":1791959625523,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Inflammation"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Burn injuries result in the release of proinflammatory mediators causing both local and systemic inflammation. Multiple organ dysfunctions secondary to systemic inflammation after severe burn contribute to adverse outcome, with the lungs being the first organ to fail. In this study, we evaluate the anti-inflammatory effects of Parecoxib, a parenteral COX-2 inhibitor, in a delayed fluid resuscitation burned rat model. Anaesthetized Sprague Dawley rats were inflicted with 45% total body surface area full-thickness scald burns and subsequently subjected to delayed resuscitation with Hartmann\u2019s solution. Parecoxib (0.1, 1.0, and 10\u2009mg\/kg) was delivered intramuscularly 20\u2009min after injury followed by 12\u2009h interval and the rats were sacrificed at 6\u2009h, 24\u2009h, and 48\u2009h. Burn rats developed elevated blood cytokines, transaminase, creatinine, and increased lung MPO levels. Animals treated with 1\u2009mg\/kg Parecoxib showed significantly reduced plasma level of CINC-1, IL-6, PGEM, and lung MPO. Treatment of 1\u2009mg\/kg Parecoxib is shown to mitigate systemic and lung inflammation without significantly affecting other organs. At present, no specific therapeutic agent is available to attenuate the systemic inflammatory response secondary to burn injury. The results suggest that Parecoxib may have the potential to be used both as an analgesic and ameliorate the effects of lung injury following burn.<\/jats:p>","DOI":"10.1155\/2014\/972645","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T01:51:48Z","timestamp":1390355508000},"page":"1-11","source":"Crossref","is-referenced-by-count":12,"title":["Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation"],"prefix":"10.1155","volume":"2014","author":[{"given":"Si Jack","family":"Chong","sequence":"first","affiliation":[{"name":"Naval Medical Service, Singapore Armed Forces, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4864-8490","authenticated-orcid":true,"given":"Yong Chiat","family":"Wong","sequence":"additional","affiliation":[{"name":"Combat Protection and Performance Lab, Defence Medical & Environmental Research Institute, DSO 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