{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:09:20Z","timestamp":1759615760581,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>In bacterial bone infections, excessively formed oxidants may result in local and systemic oxidative stress. Vitamin C is the major extracellular nonenzymatic antioxidant, also implicated in bone cells metabolism and viability. The physiological functions of vitamin C largely depend on its redox status. We sequentially assessed oxidative stress markers, hydroperoxides and malondialdehyde (MDA), total antioxidant activity (AOA), total vitamin C, ascorbic acid (Asc), and oxidized\/reduced vitamin C ratio in 137 patients with acute osteomyelitis (OM). Compared to 52 healthy controls, in OM group baseline serum hydroperoxides, MDA and oxidized\/reduced vitamin C ratio were higher whilst Asc and AOA were lower (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mi>\u00a0<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mi>\u00a0<\/mml:mi><mml:mn>0.05<\/mml:mn><\/mml:math>, resp.). On the other side, total vitamin C levels in patients and controls were similar<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mi>\u00a0<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mi>\u00a0<\/mml:mi><mml:mn>0.05<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>, thereby suggesting a relative rather than absolute vitamin C deficiency in OM. During the follow-up, oxidative stress markers, AOA, and oxidizedreduced vitamin C ratio were gradually returned to normal, while there was no apparent change of total vitamin C concentrations. Persistently high values of oxidized\/reduced vitamin C ratio and serum MDA were found in subacute OM. In conclusion, acute OM was associated with enhanced systemic oxidative stress and the shift of vitamin C redox status towards oxidized forms.<\/jats:p>","DOI":"10.1155\/2014\/975061","type":"journal-article","created":{"date-parts":[[2014,8,10]],"date-time":"2014-08-10T21:10:40Z","timestamp":1407705040000},"page":"1-7","source":"Crossref","is-referenced-by-count":10,"title":["Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-5837","authenticated-orcid":true,"given":"Rade","family":"Grbic","sequence":"first","affiliation":[{"name":"Clinics for General and Orthopedic Surgery, Medical Faculty Pristina, Anri Dinana bb, 38220 Kosovska Mitrovica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dijana J","family":"Miric","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Medical Faculty Pristina, Anri 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