{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T09:53:19Z","timestamp":1696585999677},"reference-count":26,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Pharmacology"],"published-print":{"date-parts":[[2014,3,31]]},"abstract":"<jats:p>The present study was carried out to investigate the thrombolytic and antimitotic potentiality of various extracts of fruits of <jats:italic>Ficus glomerata<\/jats:italic>, a traditional medicinal plant, using an <jats:italic>in vitro<\/jats:italic> assay method. Three crude extracts such as petroleum ether (FGPE), chloroform (FGCE), and methanol (FGME) were used for the study, with a standard (streptokinase) and negative control (sterile distilled water) to validate the method. The thrombolytic nature of the plant was found significant with methanol extract and chloroform and petroleum ether extracts have recorded mild activity, when compared with the negative control (sterile distilled water). The extracts have shown mild clot lysis, that is, 2.16%,  23.06%, 27.60%, and  47.74% of sterile distilled water, FGPE, FGCE, and FGME, respectively,  while  the  standard  (streptokinase) has shown  74.22%  clot  lysis.  FGME inhibited the root growth in number as well as length effectively, followed by FGPE, while FGCE exhibited moderate antimitotic activity and it was supported by mitotic index. Therefore, the obtained results suggest that among all the extracts of plant the methanolic extract has shown highest thrombolytic and antimitotic activity.<\/jats:p>","DOI":"10.1155\/2014\/975303","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T21:21:08Z","timestamp":1396300868000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Clot Lysis and Antimitotic Study of <i>Ficus glomerata<\/i> Roxb Fruit Extracts"],"prefix":"10.1155","volume":"2014","author":[{"given":"Kirankumar","family":"Shivasharanappa","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Gulbarga University, Gulbarga, Karnataka 585106, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Londonkar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Gulbarga University, Gulbarga, Karnataka 585106, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","year":"2004"},{"key":"2","year":"1987"},{"key":"3","year":"1955"},{"key":"4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/1099-1573(200006)14:4<278::AID-PTR592>3.0.CO;2-7","volume":"14","year":"2000","journal-title":"Phytotherapy Research"},{"issue":"1","key":"5","first-page":"69","volume":"6","year":"2009","journal-title":"National Journal of Life Sciences"},{"key":"6","first-page":"1","volume-title":"The economic significance of plants and their constituents as drug","volume":"3","year":"1989"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2004.09.016"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.08.003"},{"issue":"7","key":"9","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-112-7-529","volume":"112","year":"1990","journal-title":"Annals of Internal Medicine"},{"issue":"9","key":"10","first-page":"56","volume":"1","year":"2011","journal-title":"Journal of Applied Pharmaceutical Science"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801082"},{"issue":"7018","key":"12","first-page":"1506","volume":"311","year":"1995","journal-title":"British  Medical  Journal"},{"key":"13","first-page":"832","volume":"13","year":"2009","journal-title":"Ethnobotanical Leaflets"},{"issue":"3","key":"14","first-page":"2331","volume":"10","year":"2010","journal-title":"Journal of Cell and Tissue Research"},{"issue":"4","key":"15","first-page":"395","volume":"2","year":"2007","journal-title":"American-Eurasian Journal of Agricultural and Environmental Sciences"},{"issue":"1","key":"16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1568011023354425","volume":"2","year":"2002","journal-title":"Current Medicinal Chemistry. 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