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To sum up, the majority of evidence supported that adiponectin, omentin, and secreted frizzled-related protein 5 (SFRP5) were reduced significantly in obesity, which is associated with increased inflammation, indicated by increase of TNF<jats:italic>\u03b1<\/jats:italic>and IL-6, through activation of toll-like receptor (TLR4) and nuclear factor light chain<jats:italic>\u03ba<\/jats:italic>B (NF-<jats:italic>\u03ba<\/jats:italic>B) signaling pathways. Administration of these adipocytokines promotes weight loss and reduces inflammation. Zinc-<jats:italic>\u03b1<\/jats:italic>2-glycoprotein (ZAG), vaspin, IL-10, interleukin-1 receptor antagonist (IL-1RA), transforming growth factor<jats:italic>\u03b2<\/jats:italic>(TGF-<jats:italic>\u03b2<\/jats:italic>1), and growth differentiation factor 15 (GDF15) are also regarded as anti-inflammatories. There were controversial reports. Furthermore, there is a huge lack of studies for obesity related lung injury. The effects of adiponectin on lung transplantation, asthma, chronic obstructive pulmonary diseases (COPD), and pneumonia were anti-inflammatory and protective in lung injury. Administration of IL-10 agonist reduces mortality of acute lung injury in rabbits with acute necrotizing pancreatitis, possibly through inhibiting proinflammation and strengthening host immunity. Very limited information is available for other adipocytokines.<\/jats:p>","DOI":"10.1155\/2014\/978463","type":"journal-article","created":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T21:07:30Z","timestamp":1399842450000},"page":"1-15","source":"Crossref","is-referenced-by-count":49,"title":["Obesity, Inflammation, and Lung Injury (OILI): The Good"],"prefix":"10.1155","volume":"2014","author":[{"given":"Cheryl","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, University at Buffalo, State University of New York, 3435 Main Street, Buffalo, NY 14214, USA"},{"name":"Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, 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