{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:48:33Z","timestamp":1740142113856,"version":"3.37.3"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["AMR\/17\/2011-ECD-1"],"award-info":[{"award-number":["AMR\/17\/2011-ECD-1"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"Beta-lactamases are a superfamily of enzymes which degrade the\u03b2<\/jats:italic>-lactam class of antibiotics. They are produced endogenously by the bacterial cells, which when exposed to the\u03b2<\/jats:italic>-lactam class of antibiotics inactivate them by cleaving the\u03b2<\/jats:italic>-lactam ring. Based on the presence or absence of metallic ligand,\u03b2<\/jats:italic>-lactamases have been divided into two broad functional classes.\u03b2<\/jats:italic>-Lactamases are a constitutively evolving and expanding superfamily of enzymes, which could be further subdivided on the basis of presence\/absence of conserved motifs. In the present study we have used the MEME\/MAST suit to identify the patterns\/motifs which are specific to a particular family or subfamily of\u03b2<\/jats:italic>-lactamases. The family specific patterns\/motifs can be also useful in recognizing and assigning newly discovered\u03b2<\/jats:italic>-lactamases to one or the other family or subfamily. Cross-validation showed that the proposed method is highly sensitive and specific. We have also designed a webserver, LactFP, for this purpose.<\/jats:p>","DOI":"10.1155\/2014\/980572","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T16:02:30Z","timestamp":1392134550000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Identification of Family Specific Fingerprints in\u03b2<\/i><\/b>-Lactamase Families"],"prefix":"10.1155","volume":"2014","author":[{"given":"Abhishikha","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Biophysics, University of Delhi South Campus, New Delhi 110 021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0851-6434","authenticated-orcid":true,"given":"Neelja","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Delhi South Campus, New Delhi 110 021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Biophysics, University of Delhi South Campus, New Delhi 110 021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jugsharan Singh","family":"Virdi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Delhi South Campus, New Delhi 110 021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biophysics, University of Delhi South Campus, New Delhi 110 021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"12","key":"1","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/ajhp\/54.12.1420","volume":"54","year":"1997","journal-title":"American Journal of Health-System Pharmacy"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.2478\/s11536-008-0088-9"},{"key":"3","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1093\/clinids\/24.Supplement_1.S19","volume":"24","year":"1997","journal-title":"Clinical Infectious Diseases"},{"issue":"6","key":"4","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1128\/AAC.39.6.1211","volume":"39","year":"1995","journal-title":"Antimicrobial Agents and Chemotherapy"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1098\/rstb.1980.0049"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1093\/nar\/gkm977"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1016\/S0969-2126(96)00089-5"},{"key":"8","first-page":"581","volume":"330, part 2","year":"1998","journal-title":"Biochemical Journal"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1093\/protein\/gzr041"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1093\/nar\/gkp335"},{"key":"11","doi-asserted-by":"crossref","first-page":"D71","DOI":"10.1093\/nar\/gkr981","volume":"40","year":"2012","journal-title":"Nucleic Acids Research"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/980572.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/980572.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/980572.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T10:43:28Z","timestamp":1565174608000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2014\/980572\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":11,"alternative-id":["980572","980572"],"URL":"https:\/\/doi.org\/10.1155\/2014\/980572","relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"type":"print","value":"2356-6140"},{"type":"electronic","value":"1537-744X"}],"subject":[],"published":{"date-parts":[[2014]]}}}