{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:32:41Z","timestamp":1759336361785,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 99-2314-B-038-004-MY3","NSC 102-2321-B-038-003","NSC 99-2323-B-038-003","DOH101-TD-B-111-003"],"award-info":[{"award-number":["NSC 99-2314-B-038-004-MY3","NSC 102-2321-B-038-003","NSC 99-2323-B-038-003","DOH101-TD-B-111-003"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 99-2314-B-038-004-MY3","NSC 102-2321-B-038-003","NSC 99-2323-B-038-003","DOH101-TD-B-111-003"],"award-info":[{"award-number":["NSC 99-2314-B-038-004-MY3","NSC 102-2321-B-038-003","NSC 99-2323-B-038-003","DOH101-TD-B-111-003"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 99-2314-B-038-004-MY3","NSC 102-2321-B-038-003","NSC 99-2323-B-038-003","DOH101-TD-B-111-003"],"award-info":[{"award-number":["NSC 99-2314-B-038-004-MY3","NSC 102-2321-B-038-003","NSC 99-2323-B-038-003","DOH101-TD-B-111-003"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center of Excellence for Clinical Trial and Research in Neuroscience from the Department of Health, Taiwan","award":["NSC 99-2314-B-038-004-MY3","NSC 102-2321-B-038-003","NSC 99-2323-B-038-003","DOH101-TD-B-111-003"],"award-info":[{"award-number":["NSC 99-2314-B-038-004-MY3","NSC 102-2321-B-038-003","NSC 99-2323-B-038-003","DOH101-TD-B-111-003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>Traumatic brain injuries (TBIs) are a major health care problem worldwide. Approximately 1.5 million new TBI cases occur annually in the United States, with mortality rates ranging between 35% and 40% in severe patients. Despite the incidence of these injuries and their substantial socioeconomic implications, no specific pharmacological intervention is available for clinical use. Several studies have indicated that 300\u2009mg\/kg or 400\u2009mg\/kg of valproate (VPA) exhibits neuroprotective effects in animal models. However, humans cannot tolerate high doses of VPA. This study aims to investigate whether 30\u2009mg\/kg of VPA administered to rats affects TBIs.<jats:italic>Methods.<\/jats:italic>We used a rat model to test the effects of 30\u2009mg\/kg of VPA on TBIs. Molecular identifications for histone acetylation and phosphorylation of cAMP response element-binding protein (CREB) and phosphorylated extracellular signal regulated kinase (ERK) were performed.<jats:italic>Results.<\/jats:italic>The results indicated that treating adult rats with VPA after TBIs significantly decreased the contusion volume and recovery of contusion-related skilled forelimb reaching deficits. Applying VPA also increased histone acetylation, p-ERK, and p-CREB expression in the brain. Furthermore, applying VPA reduced inflammation, glial fibrillary acidic protein activation, and apoptosis.<jats:italic>Conclusion.<\/jats:italic>This study found that 30\u2009mg\/kg of VPA assists in treating TBIs in rat models.<\/jats:p>","DOI":"10.1155\/2014\/980657","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T16:04:35Z","timestamp":1391702675000},"page":"1-8","source":"Crossref","is-referenced-by-count":23,"title":["Low Dose of Valproate Improves Motor Function after Traumatic Brain Injury"],"prefix":"10.1155","volume":"2014","author":[{"given":"Yu-Ting","family":"Tai","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Taipei Medical University-Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Yuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, China Medical University Hospital, China Medical University, Taipei Branch, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei-Peng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Clinical Research Center, School of Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien-Jen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Research Center, Graduate Institute of Injury Prevention and Control, Wan Fang Hospital, Taipei Medical University, No. 111, Section 3, Hsing-Long Road, Taipei 116, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Lin","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Research Center, Graduate Institute of Injury Prevention and Control, Wan Fang Hospital, Taipei Medical University, No. 111, Section 3, Hsing-Long Road, Taipei 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