{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:05Z","timestamp":1740169745713,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. The relationship between number of laser burns of cyclophotocoagulation (CPC) and intraocular pressure (IOP) reduction is unknown. This animal model was established to reveal a possible dose-response-relationship between the number of applied laser burns and the IOP lowering effect.<jats:italic>Methods<\/jats:italic>. 30 chinchilla bastard rabbits were divided into 5 groups and treated with either 1, 5, 10, 20, or 30 CPC burns, respectively. IOP was followed up for 1 week. IOP reduction of a single 30-burn treatment was compared with a fractionated treatment (three sessions; one week in between; 10 burns\/session).<jats:italic>Results<\/jats:italic>. IOP reduction increases nonlinearly with the number of CPC burns (max.<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo>-<\/mml:mo><mml:mn>6.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.4<\/mml:mn><\/mml:math>\u2009mmHg). Fractionated treatment shows similar IOP reduction with less complications and more constant results compared to single session treatment.<jats:italic>Conclusions<\/jats:italic>. The study reveals a complex relationship between IOP reduction and the number of CPC burns. Fractionated CPC gives comparable IOP reduction at a higher degree of safety.<\/jats:p>","DOI":"10.1155\/2014\/983102","type":"journal-article","created":{"date-parts":[[2014,6,29]],"date-time":"2014-06-29T18:40:00Z","timestamp":1404067200000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Dose-Response-Relationship between Number of Laser Burns and IOP Reduction in Cyclophotocoagulation: An Animal Study"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8838-2194","authenticated-orcid":true,"given":"Lars","family":"Wagenfeld","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Medical-Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3021-5769","authenticated-orcid":true,"given":"Hendrik","family":"Schwarzer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University 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