{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T19:19:35Z","timestamp":1648667975072},"reference-count":39,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Tianjin Education Committee"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>We aimed to compare effectiveness of Wenxin Keli (WK) and sotalol in assisting sinus rhythm (SR) restoration from paroxysmal atrial fibrillation (PAF) caused by hyperthyroidism, as well as in maintaining SR. We randomly prescribed WK (18\u2009g tid) or sotalol (80\u2009mg bid) to 91 or 89 patients. Since it was not ethical not to give patients antiarrhythmia drugs, no control group was set. Antithyroid drugs were given to 90 patients (45 in WK group, 45 in sotalol group);<jats:sup>131<\/jats:sup>I was given to 90 patients (46 in WK group, 44 in sotalol group). Three months later, SR was obtained in 83\/91 or 80\/89 cases from WK or sotalol groups<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.762<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. By another analysis, SR was obtained in 86\/90 or 77\/90 cases from<jats:sup>131<\/jats:sup>I or ATD groups<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.022<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. Then, we randomly assigned the successfully SR-reverted patients into three groups: WK, sotalol, and control (no antiarrhythmia drug was given) groups. After twelve-month follow-up, PAF recurrence happened in 1\/54, 2\/54, and 9\/55 cases, respectively. Log-Rank test showed significant higher PAF recurrent rate in control patients than either treatment<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.06<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. We demonstrated the same efficacies of WK and sotalol to assist SR reversion from hyperthyroidism-caused PAF. We also showed that either drug could maintain SR in such patients.<\/jats:p>","DOI":"10.1155\/2015\/101904","type":"journal-article","created":{"date-parts":[[2015,5,17]],"date-time":"2015-05-17T17:05:00Z","timestamp":1431882300000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Wenxin Keli versus Sotalol for Paroxysmal Atrial Fibrillation Caused by Hyperthyroidism: A Prospective, Open Label, and Randomized Study"],"prefix":"10.1155","volume":"2015","author":[{"given":"Zhaowei","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Tianjin Medical University General Hospital, Anshan Road No. 154, Heping District, Tianjin 300052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Tianjin Medical University General Hospital, Anshan Road No. 154, Heping District, Tianjin 300052, 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