{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:20:05Z","timestamp":1774354805806,"version":"3.50.1"},"reference-count":30,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation and maturation of bone-marrow- (BM-) derived monocytes into DCs and we found suppressive effect of T-MSCs on DCs via direct contact as well as soluble mediators. Moreover, T cell proliferation, normally increased in the presence of DCs, was inhibited by T-MSCs. Differentiation of CD4<jats:sup>+<\/jats:sup>T cell subsets by the DC-T cell interaction also was inhibited by T-MSCs. The soluble mediators suppressed by T-MSCs were granulocyte-macrophage colony-stimulating factor (GM-CSF), RANTES, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). Taken together, T-MSCs exert immune modulatory function via suppression of the differentiation, maturation, and function of BM-derived DCs. Our data suggests that T-MSCs could be used as a novel source of stem cell therapy as immune modulators.<\/jats:p>","DOI":"10.1155\/2015\/106540","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T21:02:00Z","timestamp":1424120520000},"page":"1-12","source":"Crossref","is-referenced-by-count":23,"title":["Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells"],"prefix":"10.1155","volume":"2015","author":[{"given":"Minhwa","family":"Park","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Hwa","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So-Youn","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Ha","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04327.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2104"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000045055.63901.a9"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.10.3838"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2775"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/14653240701452057"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2012.706708"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05409.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.101881"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00876.x"},{"issue":"5","key":"11","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1182\/blood.V93.5.1579","volume":"93","year":"1999","journal-title":"Blood"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-074997"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/scrt75"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902007"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2657"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2009.01.005"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055487"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-154138"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103650108"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2009.09.004"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2013.135"},{"issue":"4","key":"22","first-page":"516","volume":"90","year":"2005","journal-title":"Haematologica"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0586"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0548"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.02.013"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2795"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg143"},{"issue":"2","key":"28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.32607\/20758251-2010-2-2-18-27","volume":"2","year":"2010","journal-title":"Acta Naturae"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2008.0173"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1089\/teb.2007.0216"}],"updated-by":[{"DOI":"10.1155\/2019\/9071046","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000}}],"container-title":["Stem Cells International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2015\/106540.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2015\/106540.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2015\/106540.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T01:33:32Z","timestamp":1598751212000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/sci\/2015\/106540\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":30,"alternative-id":["106540","106540"],"URL":"https:\/\/doi.org\/10.1155\/2015\/106540","relation":{},"ISSN":["1687-966X","1687-9678"],"issn-type":[{"value":"1687-966X","type":"print"},{"value":"1687-9678","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}