{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:29:09Z","timestamp":1791217749227,"version":"4.1.0"},"reference-count":140,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incompletely understood. This review aims to shed new lights into the mechanisms of bone diseases involving immune cells. In particular, we focused our attention on the major pathogenic mechanism underlying periodontal disease, psoriatic arthritis, postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, metastatic solid tumors, and multiple myeloma.<\/jats:p>","DOI":"10.1155\/2015\/108451","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T21:02:35Z","timestamp":1430168555000},"page":"1-11","source":"Crossref","is-referenced-by-count":54,"title":["Bone-Immune Cell Crosstalk: Bone Diseases"],"prefix":"10.1155","volume":"2015","author":[{"given":"Giorgio","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"D\u2019Amelio","sequence":"additional","affiliation":[{"name":"Department of Medical Science, Section of Gerontology and Bone Metabolism Diseases, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Faccio","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Washington University School of Medicine, St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-1432","authenticated-orcid":true,"given":"Giacomina","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"33","key":"1","doi-asserted-by":"crossref","first-page":"25103","DOI":"10.1074\/jbc.R109.041087","volume":"285","journal-title":"The Journal of Biological Chemistry"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2174\/187152812800392670"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/720504"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061775"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/ar2936"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000231912.24740.a5"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00350.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2187"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6713.2004.003557.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1980.tb01970.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.5.293"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6713.2004.003560.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/nri954"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302x.2003.180105.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12395"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.10.1675"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060180"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/nri2660"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.039"},{"key":"138","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140876"},{"issue":"24","key":"98","doi-asserted-by":"crossref","first-page":"12950","DOI":"10.18632\/oncotarget.2633","volume":"5","year":"2014","journal-title":"Oncotarget"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1586\/17446651.2014.936384"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1017\/s1462399408000616"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000615)88:1260;2892::aid-cncr262;3.0.co;2-y"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.4081\/reumatismo.2014.787"},{"key":"136","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.19.2146"},{"key":"137","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13056"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00535.2012"},{"issue":"9664","key":"23","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0140-6736(09)60140-9","volume":"373","year":"2009","journal-title":"The Lancet"},{"issue":"7","key":"94","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1182\/blood-2008-03-143222","volume":"112","year":"2008","journal-title":"Blood"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-283895"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-246660"},{"key":"25","first-page":"243","volume":"7","year":"2014","journal-title":"Journal of Clinical, Cosmetic and Investigational Dermatology"},{"key":"139","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-05-0883"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-06-4639"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1315231"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/path.2153"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6107"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.035"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/628289"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1186\/ar2580"},{"issue":"8","key":"28","first-page":"1502","volume":"21","year":"1994","journal-title":"The Journal of Rheumatology"},{"issue":"8","key":"29","first-page":"1507","volume":"21","year":"1994","journal-title":"The Journal of Rheumatology"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360702"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/art.38376"},{"issue":"3","key":"32","first-page":"6","volume":"5","year":"1984","journal-title":"National Institutes of Health Consensus Development Conference Statement"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.02.017"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-010-9362-3"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-1129-1"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2280"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003627"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23352"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2013.04.006"},{"issue":"1","key":"40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.abb.2010.05.027","volume":"503","year":"2010","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1402.002"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23352"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046740"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1496-7"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00210-0"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.377945"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.2"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1038\/16852"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21167"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1172\/jci200523394"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070207"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1121"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0136772100"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505168102"},{"issue":"9","key":"55","volume":"7","year":"2012","journal-title":"PloS ONE"},{"issue":"11","key":"56","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/eci.12158","volume":"43","year":"2013","journal-title":"European Journal of Clinical Investigation"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2345"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2008.02186.x"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2004.02.001"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000585"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060726"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1533207100"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1172\/jci200317215"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1172\/jci30074"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-037994"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0098"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2010.05.001"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1002\/art.20863"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013492108"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01362.x"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05216.x"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.07.001"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03181.x"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.04.022"},{"key":"75","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","volume":"402","year":"1999","journal-title":"Nature"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.06.027"},{"issue":"2","key":"77","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1182\/blood-2005-07-2719","volume":"107","year":"2006","journal-title":"Blood"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302x.2008.00494.x"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.153312"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.7.1321"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00043-13"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1607-0"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2006.03.009"},{"key":"84","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1056\/NEJMcp1012926","volume":"365","year":"2011","journal-title":"The New England Journal of Medicine"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00263-1"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2446"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.336"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2011.22"},{"key":"91"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.049"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.136"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1177\/147323001204000217"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1002\/art.21821"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1038\/nrc867"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3055"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.3747\/co.19.1011"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m202561200"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0261"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-6-80"},{"issue":"5","key":"108","first-page":"377","volume":"7","year":"2001","journal-title":"Cancer Journal"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2003.04.105"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.29.7101"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.07.036"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1152>3.0.CO;2-Q"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.7673"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400208"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(00)80218-6"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2830"},{"key":"117"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-2776(06)90001-7"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1746"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068171"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-11-3873"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.1.678"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00602.x"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0103010"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1038\/ni925"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.689"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.989"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9002-6"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130281"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-11-2905"},{"issue":"1","key":"131","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1158\/2326-6066.CIR-13-0129","volume":"2","year":"2014","journal-title":"Cancer Immunology Research"},{"key":"132","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203373"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048871"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2202"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/108451.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/108451.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/108451.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T16:52:32Z","timestamp":1717865552000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2015\/108451\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":140,"alternative-id":["108451","108451"],"URL":"https:\/\/doi.org\/10.1155\/2015\/108451","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}