{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:10:42Z","timestamp":1789495842992,"version":"build-2803163510"},"reference-count":38,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Biomaterials"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To investigate the regenerative results obtained with the association of bone marrow aspirate concentrate using the Bone Marrow Aspirate Concentrate (BMAC) method to a xenogeneic bone graft (Bio-Oss) in sinus floor elevation.<jats:italic>Materials and Methods<\/jats:italic>. Using a randomized controlled study design in eight consecutive patients (age of 55.4 \u00b1 9.2 years), 16 sinus floor lift procedures were performed with Bio-Oss alone (control group, CG,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>8<\/mml:mn><\/mml:math>) or combined with bone marrow aspirate concentrate obtained via the BMAC method (test group, TG,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>8<\/mml:mn><\/mml:math>). Six months after the grafting procedures, bone biopsies were harvested during implant placement and were analyzed by histomorphometry.<jats:italic>Results<\/jats:italic>. Histomorphometric analysis revealed a significantly higher amount<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>of vital mineralized tissue in TG when compared to the CG (55.15 \u00b1 20.91% and 27.30 \u00b1 5.55%, resp.). For nonvital mineralized tissue, TG presented a statistically higher level of Bio-Oss resorption<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>when compared with the CG (6.32 \u00b1 12.03% and 22.79 \u00b1 9.60%, resp.). Both groups (TG and CG) showed no significantly different levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) of nonmineralized tissue (38.53 \u00b1 13.08% and 49.90 \u00b1 7.64%, resp.).<jats:italic>Conclusion<\/jats:italic>. The use of bone marrow concentrate obtained by BMAC method increased bone formation in sinus lift procedures.<\/jats:p>","DOI":"10.1155\/2015\/121286","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T16:45:17Z","timestamp":1444754717000},"page":"1-7","source":"Crossref","is-referenced-by-count":31,"title":["Maxillary Sinus Augmentation Combining Bio-Oss with the Bone Marrow Aspirate Concentrate: A Histomorphometric Study in Humans"],"prefix":"10.1155","volume":"2015","author":[{"given":"Paulo Jos\u00e9","family":"Pasquali","sequence":"first","affiliation":[{"name":"Department of Implant Dentistry, S\u00e3o Leopoldo Mandic Dental School, 13 Jos\u00e9 Rocha Junqueira Street, 13045-755 Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Lucchesi","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, S\u00e3o Leopoldo Mandic Dental School, 13 Jos\u00e9 Rocha Junqueira 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