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SSc has a poor prognosis because no therapy has been shown to reverse or arrest the progression of fibrosis, representing a major unmet medical need. Recently, antifibrotic effects of PPAR<jats:italic>\u03b3<\/jats:italic>ligands have been studied<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>and some theories have emerged leading to new insights. Aberrant PPAR<jats:italic>\u03b3<\/jats:italic>function seems to be implicated in pathological fibrosis in the skin and lungs. This antifibrotic effect is mainly related to the inhibition of TGF-<jats:italic>\u03b2<\/jats:italic>\/Smad signal transduction but other pathways can be involved. This review focused on recent studies that identified PPAR<jats:italic>\u03b3<\/jats:italic>as an important novel pathway with critical roles in regulating connective tissue homeostasis, with emphasis on skin and lung fibrosis and its role on systemic sclerosis.<\/jats:p>","DOI":"10.1155\/2015\/124624","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T21:02:07Z","timestamp":1430946127000},"page":"1-12","source":"Crossref","is-referenced-by-count":60,"title":["The Role of PPAR Gamma in Systemic Sclerosis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Andr\u00e9a Tavares","family":"Dantas","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Reumatologia do Hospital das Cl\u00ednicas da Universidade Federal de Pernambuco (HC-UFPE), 50670-901 Recife, PE, Brazil"},{"name":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas da Universidade Federal de Pernambuco (LINAT-UFPE), 50670-901 Recife, PE, 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