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Purple sweet potato leaves (PSPL) are widely grown and are considered a healthy vegetable in Taiwan. PSPL contain a high content of flavonoids, and the boiling water-extracted PSPL (PSPLE) is believed to prevent metabolic syndrome. However, its efficacy has not yet been verified. Therefore, we investigated the effect of PSPLE on adipocytes.<jats:italic>Methods<\/jats:italic>. The differentiated 3T3-L1 cells used in this study were derived from preadipocytes that were differentiated into adipocytes using an adipogenic agent (insulin, dexamethasone, and 3-isobutyl-1-methylxanthine); approximately 90% of the cells were differentiated using this method.<jats:italic>Results<\/jats:italic>. Treating the differentiated 3T3-L1 cells with PSPLE caused a dose-dependent decrease in the number of adipocytes rather than preadipocytes. In addition, treatment with PSPLE resulted in apoptosis of the differentiated 3T3-L1 cells as determined by DAPI analysis and flow cytometry. PSPLE also increased the expression of cleaved caspase-3 and poly ADP-ribose polymerase (PARP). Furthermore, PSPLE induced downregulation of interleukin-6 (IL-6) and tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic>(TNF-<jats:italic>\u03b1<\/jats:italic>) gene expression in the differentiated 3T3-L1 cells.<jats:italic>Conclusions<\/jats:italic>. These results suggest that PSPLE not only induced apoptosis but also downregulated inflammation-associated genes in the differentiated 3T3-L1 cells.<\/jats:p>","DOI":"10.1155\/2015\/126302","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T01:41:19Z","timestamp":1434073279000},"page":"1-9","source":"Crossref","is-referenced-by-count":24,"title":["Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes"],"prefix":"10.1155","volume":"2015","author":[{"given":"Shou-Lun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biological Science and Technology, College of Life Sciences, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yu","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Bioscience Technology, Chung Yuan Christian University, 200 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