{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:54:47Z","timestamp":1780487687072,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"National Natural Science Foundation for the Young Scholars","award":["2013-QB01"],"award-info":[{"award-number":["2013-QB01"]}]},{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","award":["2013-QB01"],"award-info":[{"award-number":["2013-QB01"]}],"id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>This study aims to ascertain whether cytokines in the aqueous humor can predict macular edema (ME) in diabetic patients following uncomplicated phacoemulsification cataract surgery. Undiluted aqueous humor samples were obtained from 136 consecutive type 2 diabetic patients who underwent cataract surgery. The concentrations of 27 cytokines were measured in aqueous humor using the multiplex bead immunoassay. At the final follow-up examination, 116 patients completed 4 weeks of follow-up, and the incidence of macular edema was 29.31% (34 patients) 4 weeks after cataract surgery. Compared to the ME (\u2212) patients, the concentrations of interleukin-1<jats:italic>\u03b2<\/jats:italic>(IL-1<jats:italic>\u03b2<\/jats:italic>) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), IL-6 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), IL-8 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), interferon-induced protein-10 (IP-10) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>), monocyte chemotactic protein-1 (MCP-1) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), and vascular endothelial growth factor (VEGF) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) in the ME (+) patients were significantly higher. In addition, the aqueous levels of IL-1<jats:italic>\u03b2<\/jats:italic>(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.288<\/mml:mn><\/mml:math>), IL-6 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.345<\/mml:mn><\/mml:math>), IL-8 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.256<\/mml:mn><\/mml:math>), IP-10 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.377<\/mml:mn><\/mml:math>), MCP-1 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.423<\/mml:mn><\/mml:math>), and VEGF (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.279<\/mml:mn><\/mml:math>) were positively correlated with the postoperative foveal center point thickness (FCPT). However, the aqueous levels of IL-10 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>) and IL-12 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.017<\/mml:mn><\/mml:math>) were significantly lower in patients with ME. These results suggest IL-1<jats:italic>\u03b2<\/jats:italic>, IL-6, IL-8, IL-10, IL-12, IP-10, MCP-1, and VEGF may be potential predictors of postoperative macular thickness in patients with diabetes following uncomplicated phacoemulsification cataract surgery.<\/jats:p>","DOI":"10.1155\/2015\/126984","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T21:03:05Z","timestamp":1424898185000},"page":"1-8","source":"Crossref","is-referenced-by-count":41,"title":["Aqueous Cytokines as Predictors of Macular Edema in Patients with Diabetes following Uncomplicated Phacoemulsification Cataract Surgery"],"prefix":"10.1155","volume":"2015","author":[{"given":"Ning","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, 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