{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:08:54Z","timestamp":1785812934737,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006692","name":"University of Turin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006692","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Carlo Denegri Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Chronic kidney disease (CKD) and preeclampsia (PE) may both present with hypertension and proteinuria in pregnancy. Our objective is to test the possibility of distinguishing CKD from PE by means of uteroplacental flows and maternal circulating sFlt-1\/PlGF ratio.<jats:italic>Design<\/jats:italic>. Prospective analysis.<jats:italic>Population<\/jats:italic>. Seventy-six patients (35 CKD, 24 PE, and 17 other hypertensive disorders), with at least one sFlt-1\/PlGF and Doppler evaluation after the 20th gestational week.<jats:italic>Methods<\/jats:italic>. Maternal sFlt-1-PlGF were determined by immunoassays. Abnormal uterine artery Doppler was defined as resistance index \u2265 0.58. Umbilical Doppler was defined with gestational-age-adjusted Pulsatility Index. Clinical diagnosis was considered as reference. Performance of Doppler study was assessed by sensitivity analysis; sFlt-1\/PlGF cut-off values were determined by ROC curves.<jats:italic>Results<\/jats:italic>. The lowest sFlt-1\/PlGF ratio (8.29) was detected in CKD, the highest in PE (317.32) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). Uteroplacental flows were mostly preserved in CKD patients in contrast to PE (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). ROC analysis suggested two cut-points: sFlt-1\/PlGF \u2265 32.81 (sensitivity 82.93%; specificity 91.43%) and sFlt-1\/PlGF \u2265 78.75 (sensitivity 62.89%, specificity 97.14%). Specificity reached 100% at sFlt-1\/PlGF \u2265 142.21 (sensitivity: 48.8%). Early-preterm delivery was associated with higher sFlt-1\/PlGF ratio and abnormal uteroplacental flows relative to late-preterm and term deliveries.<jats:italic>Conclusions<\/jats:italic>. sFlt-1\/PlGF ratio and uteroplacental flows significantly correlated with PE or CKD and preterm delivery.<\/jats:p>","DOI":"10.1155\/2015\/127083","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T17:04:45Z","timestamp":1444323885000},"page":"1-8","source":"Crossref","is-referenced-by-count":47,"title":["Is It Possible to Differentiate Chronic Kidney Disease and Preeclampsia by means of New and Old Biomarkers? A Prospective Study"],"prefix":"10.1155","volume":"2015","author":[{"given":"Alessandro","family":"Rolfo","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, O.I.R.M-Sant\u2019Anna Hospital, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Attini","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, O.I.R.M-Sant\u2019Anna Hospital, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Tavassoli","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, O.I.R.M-Sant\u2019Anna Hospital, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Vigotti Neve","sequence":"additional","affiliation":[{"name":"SS Nephrology, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, 10043 Orbassano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Nigra","sequence":"additional","affiliation":[{"name":"Chemical-Clinical and Microbiological Analysis Laboratory, Giovanni Bosco Hospital, 10154 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Cicilano","sequence":"additional","affiliation":[{"name":"Chemical-Clinical and Microbiological Analysis Laboratory, Giovanni Bosco Hospital, 10154 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Nuzzo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, O.I.R.M-Sant\u2019Anna Hospital, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, O.I.R.M-Sant\u2019Anna Hospital, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilisa","family":"Biolcati","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, O.I.R.M-Sant\u2019Anna Hospital, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Nichelatti","sequence":"additional","affiliation":[{"name":"Service of Biostatistics, Department of Hematology, Niguarda Ca\u2019 Granda Hospital, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Gaglioti","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, O.I.R.M-Sant\u2019Anna Hospital, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullia","family":"Todros","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, O.I.R.M-Sant\u2019Anna Hospital, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgina Barbara","family":"Piccoli","sequence":"additional","affiliation":[{"name":"SS Nephrology, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, 10043 Orbassano, 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