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There is less awareness, however, of uncommon presentations where experience rather than evidence guides therapy. We report a case of primary cutaneous cryptococcosis (PCC) in a patient who had been immunosuppressed by chronic high-dose corticosteroid for the treatment of severe asthma. This case highlights the importance of early recognition of aggressive cellulitis that fails standard empiric antibiotic treatment in an immunocompromised patient. It also demonstrates successful treatment of PCC with a multispecialty approach including local debridement and fluconazole monotherapy.<\/jats:p>","DOI":"10.1155\/2015\/131356","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T21:19:13Z","timestamp":1422911953000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Primary Cutaneous Cryptococcosis Treated with Debridement and Fluconazole Monotherapy in an Immunosuppressed Patient: A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2015","author":[{"given":"Jennifer","family":"Wang","sequence":"first","affiliation":[{"name":"School of Medicine, University of Virginia, Charlottesville, VA 22903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luther","family":"Bartelt","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22903, 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