{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:41:42Z","timestamp":1785451302550,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["IIR WS725105"],"award-info":[{"award-number":["IIR WS725105"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["R01 AR060336"],"award-info":[{"award-number":["R01 AR060336"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["IIR WS725105"],"award-info":[{"award-number":["IIR WS725105"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR060336"],"award-info":[{"award-number":["R01 AR060336"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Treatment"],"published-print":{"date-parts":[[2015,12,29]]},"abstract":"<jats:p>Pregabalin, an approved treatment for fibromyalgia (FM), has been shown to decrease sympathetic nervous system (SNS) activity and inhibit sympathetically maintained pain, but its effects on exercise responses have not been reported.<jats:italic> Methods<\/jats:italic>. Using a randomized double-blind crossover design, we assessed the effect of 5 weeks of pregabalin (versus placebo) on acute cardiovascular and subjective responses to moderate exercise in 19 FM patients. Blood pressure (BP), heart rate (HR), and ratings of perceived exertion (RPE) during exercise and ratings of pain, physical fatigue, and mental fatigue before, during, and for 48 hours after exercise were compared in patients on pregabalin versus placebo and also versus 18 healthy controls.<jats:italic> Results<\/jats:italic>. On placebo, exercise RPE and BP were significantly higher in FM patients than controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.04<\/mml:mn><\/mml:math>). Pregabalin responders (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">12<\/mml:mn><\/mml:math>, defined by patient satisfaction and symptom changes) had significantly lower exercise BP, HR, and RPE on pregabalin versus placebo (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.03<\/mml:mn><\/mml:math>) and no longer differed from controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.26<\/mml:mn><\/mml:math>). Cardiovascular responses of nonresponders (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">7<\/mml:mn><\/mml:math>) were not altered by pregabalin. In responders, pregabalin improved ratings of fatigue and pain (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.04<\/mml:mn><\/mml:math>), but negative effects on pain and fatigue were seen in nonresponders.<jats:italic> Conclusions<\/jats:italic>. These preliminary findings suggest that pregabalin may normalize cardiovascular and subjective responses to exercise in many FM patients.<\/jats:p>","DOI":"10.1155\/2015\/136409","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T21:01:27Z","timestamp":1451422887000},"page":"1-10","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Pregabalin on Cardiovascular Responses to Exercise and Postexercise Pain and Fatigue in Fibromyalgia: A Randomized, Double-Blind, Crossover Pilot Study"],"prefix":"10.1155","volume":"2015","author":[{"given":"Andrea T.","family":"White","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, University of Utah, Salt Lake City, UT 84112, USA"},{"name":"Department of Exercise and Sport Science, University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen C.","family":"Light","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda","family":"Bateman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Utah, Salt Lake City, UT 84112, USA"},{"name":"Bateman Horne Center of Excellence, Salt Lake City, UT 84102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald W.","family":"Hughen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Vanhaitsma","sequence":"additional","affiliation":[{"name":"Department of Exercise and Sport Science, University of Utah, Salt Lake City, UT 84112, USA"},{"name":"Department of Kinesiology, Westmont College, Santa Barbara, CA 93108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Light","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"issue":"2","key":"2","first-page":"E217","volume":"14","year":"2011","journal-title":"Pain Physician"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.2.221"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230x-6-26"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/030097400750001798"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/art.20983"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.01.009"},{"issue":"5","key":"8","first-page":"S138","volume":"16","year":"2010","journal-title":"The American Journal of Managed 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