{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T06:23:24Z","timestamp":1751091804261},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Gyrate atrophy is a rare genetical metabolic disorder affecting vision. Here, we report a 9-year-old boy with gyrate atrophy associated with bilateral macular edema at the time of diagnosis and the effect of long term metabolic control on macular edema.<jats:italic>Case Presentation<\/jats:italic>. A 9-year-old boy presented with a complaint of low visual acuity (best corrected visual acuity: 20\/80 in both eyes, refractive error: \u221212.00\u2009D). Dilated fundus examination revealed multiple bilateral, sharply defined, and scalloped chorioretinal atrophy areas in the midperipheral and peripheral zone. Spectral-domain optical coherence tomography revealed bilateral cystoid macular edema in both eyes. Serum ornithine level was high (622\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L). An arginine-restricted diet reduced serum ornithine level (55\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L). However, visual findings including macular edema remained unchanged in 2 years of follow-up.<jats:italic>Conclusion<\/jats:italic>. Arginine-restricted diet did not improve macular edema in our patient with gyrate atrophy. A more comprehensive understanding of the underlying factors for macular edema will lead to the development of effective therapies.<\/jats:p>","DOI":"10.1155\/2015\/137270","type":"journal-article","created":{"date-parts":[[2015,12,6]],"date-time":"2015-12-06T21:01:23Z","timestamp":1449435683000},"page":"1-3","source":"Crossref","is-referenced-by-count":2,"title":["Arginine-Restricted Therapy Resistant Bilateral Macular Edema Associated with Gyrate Atrophy"],"prefix":"10.1155","volume":"2015","author":[{"given":"Sibel","family":"Doguizi","sequence":"first","affiliation":[{"name":"Ulucanlar Eye Training and Research Hospital, Department of Ophthalmology, 06240 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ali","family":"Sekeroglu","sequence":"additional","affiliation":[{"name":"Ulucanlar Eye Training and Research Hospital, Department of Ophthalmology, 06240 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Alpaslan","family":"Anayol","sequence":"additional","affiliation":[{"name":"Ulucanlar Eye Training and Research Hospital, Department of Ophthalmology, 06240 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelin","family":"Yilmazbas","sequence":"additional","affiliation":[{"name":"Ulucanlar Eye Training and Research Hospital, Department of Ophthalmology, 06240 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-199303320-00021"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(81)35031-3"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140495035"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-198909020-00014"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702009"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.12.083"},{"issue":"1","key":"7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1755-3768.1987.tb08499.x","volume":"65","year":"1987","journal-title":"Acta Ophthalmologica"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.09.017"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-014-9426-1"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1981.03930020076005"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1023\/a:1006044107353"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00395.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.11.006"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-27492007000500024"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2015\/137270.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2015\/137270.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2015\/137270.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T21:54:49Z","timestamp":1718229289000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criopm\/2015\/137270\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":14,"alternative-id":["137270","137270"],"URL":"https:\/\/doi.org\/10.1155\/2015\/137270","relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"value":"2090-6722","type":"print"},{"value":"2090-6730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}