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In the pathogenesis of PD, subgingival complex bacterial biofilm induces inflammation that leads to connective tissue degradation and alveolar bone resorption around the teeth. In health, junctional epithelium seals the gingiva to the tooth enamel, thus preventing bacteria from entering the gingivae. Chronic PD involves major pathogens (\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    ,\n                    <jats:italic>Treponema denticola<\/jats:italic>\n                    , and\n                    <jats:italic>Tannerella forsythia<\/jats:italic>\n                    ) which have an immune armoury that can circumvent host\u2019s immune surveillance to create and maintain an inflammatory mediator rich and toxic environment to grow and survive. The neurodegenerative condition, AD, is characterised by poor memory and specific hallmark proteins; periodontal pathogens are increasingly being linked with this dementing condition. It is therefore becoming important to understand associations of periodontitis with relevance to late\u2010onset AD. The aim of this review is to discuss the relevance of finding the keystone periodontal pathogen\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    in AD brains and its plausible contribution to the aetiological hypothesis of this dementing condition.\n                  <\/jats:p>","DOI":"10.1155\/2015\/137357","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T17:03:12Z","timestamp":1430413392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":183,"title":["<i>Porphyromonas gingivalis<\/i>\n                    Periodontal Infection and Its Putative Links with Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"Sim K.","family":"Singhrao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmyya","family":"Kesavalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"StJohn","family":"Crean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,30]]},"reference":[{"key":"e_1_2_16_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01139.x"},{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.071068"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2873"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2013.04.004"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097811"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-121918"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140315"},{"key":"e_1_2_16_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12065"},{"key":"e_1_2_16_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000165511.52746.1f"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.01.008"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077756"},{"key":"e_1_2_16_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1998.tb00117.x"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13044295"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.2010.01664.x"},{"key":"e_1_2_16_15_2","volume-title":"Periodontal Diseases\u2014A Clinician\u2032s Guide","author":"Chung W. 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