{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:58:08Z","timestamp":1790362688482,"version":"4.1.0"},"reference-count":141,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Vitamin A and its derivatives, the retinoids, are micronutrient necessary for the human diet in order to maintain several cellular functions from human development to adulthood and also through aging. Furthermore, vitamin A and retinoids are utilized pharmacologically in the treatment of some diseases, as, for instance, dermatological disturbances and some types of cancer. In spite of being an essential micronutrient with clinical application, vitamin A exerts several toxic effects regarding redox environment and mitochondrial function. Moreover, decreased life quality and increased mortality rates among vitamin A supplements users have been reported. However, the exact mechanism by which vitamin A elicits its deleterious effects is not clear yet. In this review, the role of mitochondrial dysfunction in the mechanism of vitamin A-induced toxicity is discussed.<\/jats:p>","DOI":"10.1155\/2015\/140267","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T21:03:37Z","timestamp":1432069417000},"page":"1-13","source":"Crossref","is-referenced-by-count":79,"title":["Vitamin A and Retinoids as Mitochondrial Toxicants"],"prefix":"10.1155","volume":"2015","author":[{"given":"Marcos Roberto","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Department of Chemistry, ICET, Federal University of Mato Grosso (UFMT), Avenida Fernando Correa da Costa, No. 2367, 78060-900 Cuiab\u00e1, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"2902S","volume":"131","year":"2002","journal-title":"Journal of Nutrition"},{"issue":"1","key":"2","doi-asserted-by":"crossref","first-page":"290S","DOI":"10.1093\/jn\/134.1.290S","volume":"134","year":"2004","journal-title":"The Journal of Nutrition"},{"issue":"9","key":"3","doi-asserted-by":"crossref","first-page":"2907S","DOI":"10.1093\/jn\/132.9.2907S","volume":"132","year":"2002","journal-title":"Journal of Nutrition"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6874.366"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(90)90013-y"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(91)90057-Z"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1053\/beha.2000.0121"},{"issue":"6","key":"8","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/ajcn\/78.6.1152","volume":"78","year":"2003","journal-title":"American Journal of Clinical Nutrition"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3181\/0706-mr-158"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.057547"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0550"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114514000166"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/BF02935566"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/s0079-6603(08)60722-9"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.05.004"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(98)00266-4"},{"issue":"3","key":"17","first-page":"126","volume":"3","year":"2014","journal-title":"Hepatobiliary Surgery and Nutrition"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-9050-5_6"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.012"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.034629"},{"issue":"3","key":"21","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1042\/bj0240692","volume":"24","year":"1930","journal-title":"Biochemical Journal"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.103004.142743"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.01.005"},{"issue":"11","key":"24","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1093\/jn\/113.11.2184","volume":"113","year":"1983","journal-title":"Journal of Nutrition"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3390\/nu5093563"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2003.151"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00410.2002"},{"issue":"1","key":"28","doi-asserted-by":"crossref","first-page":"G95","DOI":"10.1152\/ajpgi.2001.280.1.G95","volume":"280","year":"2001","journal-title":"American Journal of Physiology\u2014Gastrointestinal and Liver Physiology"},{"issue":"3","key":"29","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/0016-5085(93)90908-U","volume":"105","year":"1993","journal-title":"Gastroenterology"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(80)90050-9"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(87)90075-0"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/s0955-2863(00)00156-x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1079\/bjn19720094"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1079\/bjn19980026"},{"issue":"8","key":"35","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/S0022-2275(20)41501-9","volume":"36","year":"1995","journal-title":"Journal of Lipid Research"},{"issue":"1","key":"36","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/ajcn\/62.1.110","volume":"62","year":"1995","journal-title":"The American Journal of Clinical Nutrition"},{"issue":"1","key":"37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/ajcn\/77.1.12","volume":"77","year":"2003","journal-title":"The American Journal of Clinical Nutrition"},{"issue":"6","key":"38","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/cs0930585","volume":"93","year":"1997","journal-title":"Clinical Science"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1021\/bi00502a015"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136244"},{"issue":"6","key":"41","first-page":"E686","volume":"235","year":"1978","journal-title":"The American Journal of Physiology"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2003.50082"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.18.1.19"},{"issue":"9","key":"44","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1096\/fasebj.10.9.8801182","volume":"10","year":"1996","journal-title":"FASEB Journal"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3480481"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90482-0"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20242"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20158"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.16.7772"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5352.863"},{"issue":"26","key":"51","doi-asserted-by":"crossref","first-page":"18365","DOI":"10.1016\/S0021-9258(19)36970-4","volume":"267","year":"1992","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"52","first-page":"397","volume":"21","year":"1984","journal-title":"Indian Journal of Biochemistry and Biophysics"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(80)90242-4"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1997.tb02213.x"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-2952(99)00149-5"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250256"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2005.07.016"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2007.08.018"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2013.01.020"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2014.04.003"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804505200"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-560060"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.07.008"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.07.008"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2007.07.002"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-007-9438-2"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.12.020"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.02.006"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.10.002"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5215.2011.00588.x"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0372-3"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.03.046"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-008-9111-9"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.3109\/10715761003636849"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.2791"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.09.003"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2011.00943.x"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.08.006"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2006.03.013"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1007\/s10541-005-0102-7"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00789.x"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.r113.472936"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.07.005"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5493.985"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m000206200"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6365"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03907.x"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12966"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201402281"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2012.01.005"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113190990406"},{"issue":"3","key":"91","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj1340707","volume":"134","year":"1973","journal-title":"Biochemical Journal"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.03.016"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1038\/ni1202-1129"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2005.02.004"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.243"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00476.x"},{"issue":"10","key":"97","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.1016\/S0021-9258(19)83842-5","volume":"257","year":"1982","journal-title":"The Journal of Biological Chemistry"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.2174\/138920308785132677"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.09.026"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1007\/BF03168215"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07132.x"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1016\/s1353-8020(09)70817-x"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.205"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-396456-4.00006-7"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1054\/ceca.2000.0170"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3005"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1658508"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl066"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1080\/15216540601047767"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00892.x"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1868"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903563106"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2014.00059"},{"key":"116","series-title":"Handbook of Experimental Pharmacology","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-3-642-45106-5_9","volume-title":"BDNF and synaptic plasticity, cognitive function, and dysfunction","volume":"220","year":"2014"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1038\/35049004"},{"issue":"23","key":"118","doi-asserted-by":"crossref","first-page":"8212","DOI":"10.1523\/JNEUROSCI.23-23-08212.2003","volume":"23","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03578.x"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.5.983"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0014-z"},{"key":"131","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2012.01.008"},{"issue":"2","key":"132","first-page":"92","volume":"88","year":"2011","journal-title":"Cutis"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117730"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05334.x"},{"key":"137","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.8.842"},{"issue":"9","key":"138","volume":"8","year":"2013","journal-title":"PloS one"},{"issue":"1","key":"139","first-page":"40","volume":"17","year":"2014","journal-title":"Current Opinion and Clinical Nutrition and Metabolic Care"},{"key":"141","doi-asserted-by":"publisher","DOI":"10.1086\/500366"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199753030-00003"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.2174\/156652406775574523"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00291"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1016\/s0925-4439(98)00082-9"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306336101"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1308.059"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1615\/jenvironpatholtoxicoloncol.v27.i3.40"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-4328(02)00268-1"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.03.004"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.05.027"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.1038\/nrn983"},{"key":"136","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2014-0046"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.21.1550"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2015\/140267.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2015\/140267.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2015\/140267.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T15:00:43Z","timestamp":1652022043000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/omcl\/2015\/140267\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":141,"alternative-id":["140267","140267"],"URL":"https:\/\/doi.org\/10.1155\/2015\/140267","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}