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Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis since most patients present with mutation(s) in the <jats:italic>JAK2, MPL,<\/jats:italic> or <jats:italic>CALR<\/jats:italic> genes. Yet the roles played by these mutations in the pathogenesis and main complications of the different subtypes of MPNs are not fully elucidated. Importantly, chronic inflammation has long been associated with MPN disease and some of the symptoms and complications can be linked to inflammation. Moreover, the JAK inhibitor clinical trials showed that the reduction of symptoms linked to inflammation was beneficial to patients even in the absence of significant decrease in the <jats:italic>JAK2<\/jats:italic>\u2010V617F mutant load. These observations suggested that part of the inflammation observed in patients with <jats:italic>JAK2<\/jats:italic>\u2010mutated MPNs may not be the consequence of <jats:italic>JAK2<\/jats:italic> mutation. The aim of this paper is to review the different aspects of inflammation in MPNs, the molecular mechanisms involved, the role of specific genetic defects, and the evidence that increased production of certain  cytokines depends or not on  MPN\u2010associated mutations, and to discuss possible nongenetic causes of inflammation.<\/jats:p>","DOI":"10.1155\/2015\/145293","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T23:13:28Z","timestamp":1444691608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5444-4406","authenticated-orcid":false,"given":"Sylvie","family":"Hermouet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Bigot-Corbel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Gardie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,11]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24440"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90077-1"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03546"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa051113"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030270"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa065202"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13224"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1311347"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1312542"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-013540"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.23"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652410791316968"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986712802002554"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-009605"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-245381"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-372813"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209916"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-537167"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2013.876356"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2014.08.003"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1615\/critrevoncog.v15.i1-2.20"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.105"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200107123450206"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1999.0533"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21327"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2015.2079"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001881"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(03)00154-5"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-007146"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199505043321802"},{"key":"e_1_2_10_32_2","volume-title":"Microbes and Malignancy. 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