{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:18:00Z","timestamp":1793067480017,"version":"4.5.0"},"reference-count":31,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Mexican Institute for Social Security","award":["FIS\/IMSS\/PROTMD11\/998"],"award-info":[{"award-number":["FIS\/IMSS\/PROTMD11\/998"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD).<jats:italic>Methods<\/jats:italic>. In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared with 42 RA without lung involvement (RA only). Characteristics related to RA-ILD were assessed in all of the patients and serum anti-CCP2 titers quantified.<jats:italic>Results<\/jats:italic>. Higher anti-CCP2 titers were found in RA-ILD compared with RA only (medians 77.9 versus 30.2\u2009U\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). In the logistic regression analysis after adjustment for age, disease duration (DD), smoke exposure, disease activity, functioning, erythrocyte sedimentation rate, and methotrexate (MTX) treatment duration, the characteristics associated with RA-ILD were higher anti-CCP2 titers (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>) and + RF (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>). In multivariate linear regression, the variables associated with severity of ground-glass score were anti-CCP2 titers (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>) and with fibrosis score DD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), anti-CCP2 titers (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), and MTX treatment duration (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Anti-CCP2 antibodies are markers of severity and extent of RA-ILD in HRCT. Further longitudinal studies are required to identify if higher anti-CCP2 titers are associated with worst prognosis in RA-ILD.<\/jats:p>","DOI":"10.1155\/2015\/151626","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T21:03:33Z","timestamp":1432069413000},"page":"1-10","source":"Crossref","is-referenced-by-count":45,"title":["Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Alberto Daniel","family":"Rocha-Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Centro Universitario de Tonal\u00e1 (CUTONALA), Universidad de Guadalajara (U de G), 48525 Tonala, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ponce-Guarneros","sequence":"additional","affiliation":[{"name":"Programa de Becarios de Investigaci\u00f3n del Instituto Mexicano del Seguro Social (IMSS) y Programa de Doctorado en Farmacolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), U de G, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Ivan","family":"Gamez-Nava","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Epidemiolog\u00eda Cl\u00ednica y Divisi\u00f3n de Investigaci\u00f3n en Salud Unidad Medica de Alta Especialidad, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, JAL, Mexico"},{"name":"Programa de Doctorado en Salud P\u00fablica, CUCS, U de G, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Maria","family":"Olivas-Flores","sequence":"additional","affiliation":[{"name":"Hospital General Regional-180, IMSS, 45650 Tlajomulco, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Mej\u00eda","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Respiratorias \u201cDr. Ismael Cos\u00edo Villegas\u201d (INER), 14080 Mexico City, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ju\u00e1rez-Contreras","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna-Reumatolog\u00eda y Departamento de Medicina Interna-Neumolog\u00eda, HGR-110, IMSS, 44700 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Aurora","family":"Mart\u00ednez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, CUCS, U de G, 44340 Guadalajara, JAL, Mexico"},{"name":"Instituto de Investigacion en Reumatologia y del Sistema Musculoesqueletico, CUCS and Division de Medicina Interna, Servicio de Reumatologia OPD Hospital Civil Dr. 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