{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:33:00Z","timestamp":1793817180541,"version":"4.6.1"},"reference-count":209,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"French Institute of Health and Medical Research"},{"DOI":"10.13039\/501100004794","name":"National Center for Scientific Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    Hyperphosphorylation and aggregation of the microtubule-associated protein tau in brain, are pathological hallmarks of a large family of neurodegenerative disorders, named tauopathies, which include Alzheimer\u2019s disease. It has been shown that increased phosphorylation of tau destabilizes tau-microtubule interactions, leading to microtubule instability, transport defects along microtubules, and ultimately neuronal death. However, although mutations of the\n                    <jats:italic>MAPT<\/jats:italic>\n                    gene have been detected in familial early-onset tauopathies, causative events in the more frequent sporadic late-onset forms and relationships between tau hyperphosphorylation and neurodegeneration remain largely elusive. Oxidative stress is a further pathological hallmark of tauopathies, but its precise role in the disease process is poorly understood. Another open question is the source of reactive oxygen species, which induce oxidative stress in brain neurons. Mitochondria have been classically viewed as a major source for oxidative stress, but microglial cells were recently identified as reactive oxygen species producers in tauopathies. Here we review the complex relationships between tau pathology and oxidative stress, placing emphasis on (i) tau protein function, (ii) origin and consequences of reactive oxygen species production, and (iii) links between tau phosphorylation and oxidative stress. Further, we go on to discuss the hypothesis that tau hyperphosphorylation and oxidative stress are two key components of a vicious circle, crucial in neurodegenerative tauopathies.\n                  <\/jats:p>","DOI":"10.1155\/2015\/151979","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T14:55:32Z","timestamp":1445439332000},"page":"1-17","source":"Crossref","is-referenced-by-count":241,"title":["Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?"],"prefix":"10.1155","volume":"2015","author":[{"given":"Seyedeh Maryam","family":"Alavi Naini","sequence":"first","affiliation":[{"name":"INSERM UMR 1141, H\u00f4pital Robert Debr\u00e9, Paris, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Soussi-Yanicostas","sequence":"additional","affiliation":[{"name":"INSERM UMR 1141, H\u00f4pital Robert Debr\u00e9, Paris, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(13)70090-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m206236200"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.121119298"},{"issue":"1","key":"4","first-page":"19","volume":"118","year":"2014","journal-title":"Revista Medico-Chirurgicala a Societatii de Medici si Naturalisti din Iasi"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5027"},{"issue":"1","key":"6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1152\/physiol.00024.2010","volume":"26","year":"2011","journal-title":"Physiology (Bethesda)"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.101.4.1371"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1021\/bi800783d"},{"issue":"18","key":"9","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.1523\/JNEUROSCI.16-18-05583.1996","volume":"16","year":"1996","journal-title":"The Journal of Neuroscience"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199708180-00029"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.21.8422"},{"issue":"3","key":"12","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1523\/JNEUROSCI.22-03-00698.2002","volume":"22","year":"2002","journal-title":"The Journal of Neuroscience"},{"issue":"2","key":"13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/j.1460-2075.1989.tb03390.x","volume":"8","year":"1989","journal-title":"The EMBO Journal"},{"issue":"3","key":"14","first-page":"271","volume":"387","year":"1986","journal-title":"Brain Research"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5395.1914"},{"issue":"13","key":"16","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1002\/j.1460-2075.1990.tb07870.x","volume":"9","year":"1990","journal-title":"The EMBO Journal"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4378"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.05.001"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.46.28741"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m512786200"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m510127200"},{"issue":"3","key":"22","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0002-9440(10)63462-1","volume":"163","year":"2003","journal-title":"The American Journal of Pathology"},{"issue":"4","key":"23","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1046\/j.1471-4159.1995.65041658.x","volume":"65","year":"1995","journal-title":"The Journal of Neurochemistry"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1255"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2008.00197.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000173890.79058.1d"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1630428100"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.96"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp099"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws013"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.30.1.397"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m501565200"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200201048"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.03.031"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5392-05.2006"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5206com"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9637"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.36.25490"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(96)01386-5"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2005.08.014"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.09.002"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03378"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m709715200"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m000389200"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.31.18342"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06102.x"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22188"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20712"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076057"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1038\/nri2473"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152993"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.143.3.777"},{"issue":"14","key":"53","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1242\/jcs.112.14.2355","volume":"112","year":"1999","journal-title":"Journal of Cell Science"},{"issue":"18","key":"54","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1523\/JNEUROSCI.16-18-05727.1996","volume":"16","year":"1996","journal-title":"The Journal of Neuroscience"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21154"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5242-07.2008"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200108057"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808084105"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1038\/369488a0"},{"key":"60","first-page":"1179","volume":"114, part 6","year":"2001","journal-title":"Journal of Cell Science"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1038\/82868"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1097\/wnr.0b013e32818b2a0b"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.5.989"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00964-7"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2613"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20798"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141736"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.4152-10.2011"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.5.1327"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.1999.0279"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01879.x"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.4637-04.2005"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1065-09.2009"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7735com"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-0173(01)00055-8"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1038\/nm0796-783"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.04.007"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-109181"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3279-05.2005"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1126\/science.1113694"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.11.030"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01217-4"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5598"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(98)01696-2"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh147"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1021\/bi000850r"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00508-6"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0752155.x"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-30"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg090"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00124-6"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1086\/302256"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2001.00729.x"},{"issue":"12","key":"200","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1091\/mbc.11.12.4093","volume":"11","year":"2000","journal-title":"Molecular Biology of the Cell"},{"issue":"6","key":"201","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/00005072-199906000-00011","volume":"58","year":"1999","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"202","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202205599"},{"issue":"1","key":"203","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1523\/JNEUROSCI.22-01-00133.2002","volume":"22","year":"2002","journal-title":"The Journal of Neuroscience"},{"issue":"6","key":"204","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/1531-8249(200012)48:6<939::AID-ANA17>3.0.CO;2-1","volume":"48","year":"2000","journal-title":"Annals of Neurology"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00083"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb07444.x"},{"issue":"4","key":"96","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1046\/j.1471-4159.1997.68041590.x","volume":"68","year":"1997","journal-title":"Journal of Neurochemistry"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.03.007"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m601849200"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5561-03.2004"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(99)01480-5"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90117-v"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.07.003"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.09.83"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2011.586690"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91476-u"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90264-X"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2009.01.003"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-8993(98)00296-0"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199909000-00011"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(03)00259-9"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070904"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2009-1116"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1021\/bi051635j"},{"issue":"3","key":"114","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/bj3550609","volume":"355","year":"2001","journal-title":"Biochemical Journal"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11156"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81200-3"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04391.x"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2010-1317"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.8.5535"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb03603.x"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7630"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.08.077"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.09.035"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m000808200"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m507753200"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2824-07.2008"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9566-7"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410106"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1016\/s0197-4580(00)00202-5"},{"issue":"1","key":"130","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/nbdi.2000.0335","volume":"8","year":"2001","journal-title":"Neurobiology of Disease"},{"key":"131","doi-asserted-by":"publisher","DOI":"10.1021\/bi1016233"},{"issue":"3","key":"132","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1093\/genetics\/165.3.1233","volume":"165","year":"2003","journal-title":"Genetics"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062382"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5245-10.2011"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.1038\/383550a0"},{"issue":"3","key":"136","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1046\/j.1471-4159.1996.67031183.x","volume":"67","year":"1996","journal-title":"Journal of Neurochemistry"},{"issue":"6","key":"137","first-page":"2181","volume":"150","year":"1997","journal-title":"The American Journal of Pathology"},{"key":"138","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"issue":"9","key":"139","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/jnen\/63.9.911","volume":"63","year":"2004","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m112.346072"},{"key":"141","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301440110"},{"key":"142","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1901"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2642-12.2013"},{"key":"144","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.033"},{"key":"145","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031302"},{"key":"146","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2006.00666.x"},{"issue":"1","key":"147","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/(SICI)1097-4547(20000101)59:1<11::AID-JNR2>3.0.CO;2-O","volume":"59","year":"2000","journal-title":"Journal of Neuroscience Research"},{"key":"148","doi-asserted-by":"publisher","DOI":"10.2217\/17520363.2.4.363"},{"key":"149","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006254"},{"issue":"7","key":"150","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","volume":"68","year":"2009","journal-title":"Journal of Neuropathology & Experimental Neurology"},{"key":"151","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws307"},{"key":"152","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318212bc7b"},{"key":"153","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22300"},{"key":"154","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1644-07.2007"},{"key":"155","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.12.017"},{"key":"156","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.010"},{"key":"157","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt323"},{"key":"158","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10119"},{"key":"159","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.472"},{"key":"160","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0563-x"},{"key":"161","doi-asserted-by":"publisher","DOI":"10.2174\/157015909787602823"},{"key":"162","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00535-x"},{"key":"163","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e31818e06f3"},{"key":"164","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-004-0055-z"},{"key":"165","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0730881.x"},{"issue":"5","key":"166","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/jnen\/59.5.393","volume":"59","year":"2000","journal-title":"Journal of Neuropathology & Experimental Neurology"},{"key":"167","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02244-8"},{"key":"168","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01139.x"},{"key":"169","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m500356200"},{"key":"170","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)01113-9"},{"key":"171","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.09.021"},{"key":"172","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-186650"},{"key":"173","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04986.x"},{"key":"174","doi-asserted-by":"publisher","DOI":"10.1172\/jci28769"},{"key":"175","doi-asserted-by":"publisher","DOI":"10.1089\/152308603770310220"},{"issue":"1\u20133","key":"176","first-page":"205","volume":"31","year":"2005","journal-title":"Molecular Neurobiology"},{"key":"177","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.11.010"},{"key":"178","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02323-1"},{"key":"179","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.11.005"},{"key":"180","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10525"},{"key":"181","doi-asserted-by":"publisher","DOI":"10.1021\/bi001876l"},{"key":"182","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000536"},{"key":"183","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.113670"},{"key":"184","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.08.004"},{"key":"185","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10511"},{"issue":"6","key":"186","first-page":"659","volume":"6","year":"2004","journal-title":"Journal of Alzheimer's Disease"},{"key":"187","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.10.055"},{"key":"188","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00483-3"},{"issue":"12","key":"189","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/jnen\/60.12.1190","volume":"60","year":"2001","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"190","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02895.x"},{"key":"191","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.05.005"},{"key":"192","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.2.113"},{"key":"193","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.01.017"},{"key":"194","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0720576.x"},{"key":"195","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00200-1"},{"issue":"18","key":"196","doi-asserted-by":"crossref","first-page":"7084","DOI":"10.1523\/JNEUROSCI.23-18-07084.2003","volume":"23","year":"2003","journal-title":"The Journal of Neuroscience"},{"key":"197","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.07.001"},{"key":"198","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.04.037"},{"key":"199","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2009-1107"},{"key":"205","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.05.030"},{"key":"206","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.04.033"},{"key":"207","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2012-111298"},{"key":"208","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2011-111190"},{"key":"209","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu080"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2015\/151979.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2015\/151979.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2015\/151979.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T18:30:22Z","timestamp":1718130622000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/omcl\/2015\/151979\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":209,"alternative-id":["151979","151979"],"URL":"https:\/\/doi.org\/10.1155\/2015\/151979","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}