{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:42:13Z","timestamp":1790638933650,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Interleukin-10 overproduction has been associated with worse prognosis in human cutaneous leishmaniasis, while IFN-<jats:italic>\u03b3<\/jats:italic>-dependent responses are associated with parasite killing and host protection. Innovative strategies are needed to overcome therapeutic failure observed in endemic areas. The use of monoclonal antibody-based immunotherapy targeting IL-10 cytokine was evaluated here. Partial IL-10 blockade in<jats:italic>Leishmania braziliensis<\/jats:italic>whole soluble antigen-stimulated cells from endemic area CL patients with active or healed lesions and asymptomatic controls was evaluated. Overall decrease in IL-10, IL-4, and TNF-<jats:italic>\u03b1<\/jats:italic>production was observed in all groups of subjects. Only patients with active lesions still produced some levels of TNF-<jats:italic>\u03b1<\/jats:italic>after anti-IL-10 stimulation in association with<jats:italic>Leishmania<\/jats:italic>antigens. Moreover, this strategy showed limited modulatory effects on IFN-<jats:italic>\u03b3<\/jats:italic>-dependent chemokine CXCL10 production. Results suggest the potential immunotherapeutic use of partial IL-10 blockade in localized cutaneous leishmaniasis.<\/jats:p>","DOI":"10.1155\/2015\/152741","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T21:10:09Z","timestamp":1443733809000},"page":"1-5","source":"Crossref","is-referenced-by-count":22,"title":["Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Lucio Roberto","family":"Castellano","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, Federal University of Tri\u00e2ngulo Mineiro, 38025-180 Uberaba, MG, Brazil"},{"name":"Human Immunology Research and Education Group-GEPIH, Technical Health School, Federal University of Para\u00edba, 58051-900 Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Argiro","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology Mycology, INSERM U399, Faculty of Medicine, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helia","family":"Dessein","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology Mycology, INSERM U399, Faculty of Medicine, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Dessein","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology Mycology, INSERM U399, Faculty of Medicine, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Vin\u00edcius","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Federal University of Tri\u00e2ngulo Mineiro, 38025-180 Uberaba, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalmo","family":"Correia","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Federal University of Tri\u00e2ngulo Mineiro, 38025-180 Uberaba, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virmondes","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Federal University of Tri\u00e2ngulo Mineiro, 38025-180 Uberaba, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1172\/jci116570"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.01398-08"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1086\/502980"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.01.007"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1086\/315071"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.6139"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065x.2008.00635.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2007.04.009"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir461"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.4"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003504"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1259"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.12.6734-6740.2002"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.12.016"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1128\/iai.73.12.7853-7859.2005"},{"issue":"6","key":"16","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.4049\/jimmunol.135.6.4144","volume":"135","year":"1985","journal-title":"Journal of Immunology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199001043220104"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.4.992"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00296"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1590\/s0037-86822006000100003"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/152741.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/152741.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/152741.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T20:40:41Z","timestamp":1692045641000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2015\/152741\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":20,"alternative-id":["152741","152741"],"URL":"https:\/\/doi.org\/10.1155\/2015\/152741","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}