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Therefore, routing in WSNs is an extremely interesting and challenging issue. In this paper, we present a novel bio-inspired trusted routing scheme (B-iTRS) based on ant colony optimization (ACO) and Physarum autonomic optimization (PAO). For trust assessment, B-iTRS monitors neighbors\u2019 behavior in real time, receives feedback from Sink, and then assesses neighbors\u2019 trusts based on the acquired information. For routing scheme, each node finds routes to the Sink based on ACO and PAO. In the process of path finding, B-iTRS senses the load and trust value of each node and then calculates the link load and link trust of the found routes to support the route selection. Moreover, B-iTRS also assesses the route based on PAO to maintain the route table. 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