{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T06:59:33Z","timestamp":1782543573818,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":144,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Medical University of Warsaw","award":["1WU\/NM 2012"],"award-info":[{"award-number":["1WU\/NM 2012"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Obstructive sleep apnoea syndrome (OSAS) brings risk of serious complications. The study objective was to assess elements of the cellular immune response in the course of OSAS. <jats:italic>Methods<\/jats:italic>. Peripheral blood (PB) lymphocytes: T, B, NK, NKT\u2010like, Th, Tc, and HLA DR+ T cells were evaluated by flow cytometry of 48 OSA patients; the concentration of adiponectin, interleukin 1<jats:italic>\u03b2<\/jats:italic>, and TNF<jats:italic>\u03b1<\/jats:italic> was measured by ELISA method. The <jats:italic>OSA complication score<\/jats:italic> was developed and used for statistical analysis. <jats:italic>Results<\/jats:italic>. The proportion of B cells and Th\/Tc ratio were significantly lower in the BP of OSA patients when compared with control subjects (median 7.9 versus 10.9%, 0.9 versus 1.5, <jats:italic>p<\/jats:italic> &lt; 0.05). The proportion of Tc, NK, NKT\u2010like, and HLADR positive T cells were elevated in OSA patients when compared with healthy subjects (36.4 versus 26.8, 15.5 versus 8.5, 5.7 versus 3.0, and 8.4 versus 4.5%, <jats:italic>p<\/jats:italic> &lt; 0.05, resp.) and were more pronounced in patients with metabolic syndrome. The grade of <jats:italic>OSA complication score<\/jats:italic> correlated with systemic inflammation markers and the proportion of B cells. The value of adiponectin\/BMI ratio correlated significantly with SpO<jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic> = 0.31, <jats:italic>p<\/jats:italic> &lt; 0.05), CRP (<jats:italic>r<\/jats:italic> = \u22120.35, <jats:italic>p<\/jats:italic> &lt; 0.05), TNF<jats:italic>\u03b1<\/jats:italic> concentration (<jats:italic>r<\/jats:italic> = \u22120.36, <jats:italic>p<\/jats:italic> &lt; 0.05), and proportion of B cells (<jats:italic>r<\/jats:italic> = 0.32, <jats:italic>p<\/jats:italic> &lt; 0.05). <jats:italic>Conclusion<\/jats:italic>. Lymphocytes B, Tc, NK, NKT\u2010like, and adiponectin are involved in systemic immune response in OSA patients possibly predisposing them to cardiovascular and metabolic complications.<\/jats:p>","DOI":"10.1155\/2015\/161579","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T21:03:41Z","timestamp":1432587821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["T, B, and NKT Cells in Systemic Inflammation in Obstructive Sleep 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