{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:33:56Z","timestamp":1761896036981},"reference-count":15,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The objective of this paper is to report a case of extramammary Paget disease of the vulva, to describe its diagnosis, surgical treatment, and outcome, and to discuss the general characteristics of this pathology. This is a rare neoplasm, found principally in areas in which apocrine and eccrine glands are numerous. This case report is relevant to the literature since the differential diagnosis of extramammary Paget disease is difficult to be done only with the macroscopic appearance of the lesion and even with the microscopic characteristics, requiring further studies, immunohistochemistry, as to differentiate pathologies. The present report describes the case of a 63-year-old patient at the Santa Casa de Miseric\u00f3rdia Hospital in Vit\u00f3ria, Esp\u00edrito Santo, Brazil, who presented with a hardened, ulcerated, and purplish lesion with hyperchromic and hypochromic spots, measuring 4\u2009cm in diameter, located on the lower third of right labium majus, close to the vaginal fourchette. A right hemivulvectomy was performed, leaving wide margins all around. The patient progressed satisfactorily following surgery. Although extramammary Paget disease is rare, its incidence increases as a function of the patient\u2019s age. Patients should be followed up closely because of the risk of persistence and\/or recurrence of the disease.<\/jats:p>","DOI":"10.1155\/2015\/162483","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T21:03:43Z","timestamp":1430255023000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Paget Disease of the Vulva: Diagnosis by Immunohistochemistry"],"prefix":"10.1155","volume":"2015","author":[{"given":"Andressa","family":"Gon\u00e7alves Amorim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Santa Casa de Miseric\u00f3rdia Hospital, 29025-023 Vit\u00f3ria, ES, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunelle","family":"Batista Fraga Mendes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Santa Casa de Miseric\u00f3rdia Hospital, 29025-023 Vit\u00f3ria, ES, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Neves Ferreira","sequence":"additional","affiliation":[{"name":"Pathology Department, Santa Casa de Miseric\u00f3rdia Hospital, Dr. Jo\u00e3o dos Santos Neves Street 143, 29025-023 Vit\u00f3ria, ES, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio","family":"Chamb\u00f4 Filho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Santa Casa de Miseric\u00f3rdia Hospital, 29025-023 Vit\u00f3ria, ES, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-7800.104474"},{"key":"2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1590\/S0100-72032004000400011","volume":"26","year":"2004","journal-title":"Revista Brasileira de Ginecologia e Obstetr\u00edcia"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gynor.2014.03.004"},{"issue":"2","key":"4","first-page":"649","volume":"34","year":"2010","journal-title":"Collegium Antropologicum"},{"key":"5","volume":"10","year":"2013","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.121.6.750"},{"key":"7","first-page":"151","volume-title":"Rare tumours of the vulva","year":"2000"},{"key":"8","first-page":"44","volume":"27","year":"2013","journal-title":"Perinatolog\u00eda y Reproducci\u00f3n Humana"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3747\/co.19.1144"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.72.858.10560346"},{"issue":"5","key":"11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1590\/S0365-05962006000500008","volume":"81","year":"2006","journal-title":"Anais Brasileiros de Dermatologia"},{"key":"12","volume":"17, article 13","year":"2011","journal-title":"Dermatology Online Journal"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.107521"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.28.s1.12.x"},{"key":"15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4143\/crt.2005.37.6.365","volume":"37","year":"2005","journal-title":"Cancer Research and Treatment"}],"container-title":["Case Reports in Dermatological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2015\/162483.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2015\/162483.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cridm\/2015\/162483.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T10:27:44Z","timestamp":1498213664000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cridm\/2015\/162483\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":15,"alternative-id":["162483","162483"],"URL":"https:\/\/doi.org\/10.1155\/2015\/162483","relation":{},"ISSN":["2090-6463","2090-6471"],"issn-type":[{"value":"2090-6463","type":"print"},{"value":"2090-6471","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}