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Treatment for MAS with intravenous cyclophosphamide resulted in remission of AOSD and a reduction in the high doses of steroids. Efficacy of biologics against MAS in AOSD is unclear. Cyclophosphamide, a conventional cytotoxic agent, should be considered as one of the therapeutic options for refractory types of AOSD with MAS.<\/jats:p>","DOI":"10.1155\/2015\/163952","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T16:01:09Z","timestamp":1450800069000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still\u2019s Disease"],"prefix":"10.1155","volume":"2015","author":[{"given":"Yoshika","family":"Tsuji","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine and Rheumatology, Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine and Rheumatology, Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8562, 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