{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:59:49Z","timestamp":1790006389750,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"University of Bergen"},{"DOI":"10.13039\/501100010586","name":"Haukeland University Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010586","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Western Norway Regional Health Authority, Innovest"},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"KG Jebsen Foundation"},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>Two adjacent regions upstream<jats:italic>CDKN2B<\/jats:italic>on chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD). The precise location and number of risk variants have not been completely delineated and a possible synergistic relationship between the adjacent regions is not fully addressed. By a population based cross-sectional case-control design, we genotyped 18 SNPs upstream of<jats:italic>CDKN2B<\/jats:italic>tagging 138\u2009kb in and around two LD-blocks associated with CVD and T2D and investigated associations with T2D, angina pectoris (AP), myocardial infarction (MI), coronary heart disease (CHD; AP or AMI), and stroke using 5,564 subjects from HUNT2.<jats:italic>Results.<\/jats:italic>Single point and haplotype analysis showed evidence for only one common T2D risk haplotype (<jats:italic>rs10757282\u2223rs10811661<\/jats:italic>: OR = 1.19,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>2.0<\/mml:mn><mml:mo>\u00d7<\/mml:mo><mml:msup><mml:mrow><mml:mn>10<\/mml:mn><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><mml:mn>3<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math>) in the region. We confirmed the strong association between SNPs in the 60\u2009kb CVD region with AP, MI, and CHD<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. Conditioning on the lead SNPs in the region, we observed two suggestive independent single SNP association signals for MI,<jats:italic>rs2065501<\/jats:italic>\u2009\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.03<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>and<jats:italic>rs3217986<\/jats:italic>\u2009\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>.<jats:italic>Conclusions.<\/jats:italic>We confirmed the association of known variants within the 9p21 interval with T2D and CHD. Our results further suggest that additional CHD susceptibility variants exist in this region.<\/jats:p>","DOI":"10.1155\/2015\/164652","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T23:26:05Z","timestamp":1431991565000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey)"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5612-2985","authenticated-orcid":true,"given":"\u00d8yvind","family":"Helgeland","sequence":"first","affiliation":[{"name":"KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"Department of Pediatrics, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens K.","family":"Hertel","sequence":"additional","affiliation":[{"name":"KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"Department of Pediatrics, Haukeland University Hospital, 5021 Bergen, Norway"},{"name":"Morbid Obesity Center, Vestfold Hospital Trust, 3116 T\u00f8nsberg, Norway"},{"name":"Department of Heart Disease, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1847-3079","authenticated-orcid":true,"given":"Anders","family":"Molven","sequence":"additional","affiliation":[{"name":"KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway"},{"name":"Department of Pathology, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"R\u00e6der","sequence":"additional","affiliation":[{"name":"KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"Department of Pediatrics, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl G. P.","family":"Platou","sequence":"additional","affiliation":[{"name":"HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway"},{"name":"Department of Internal Medicine, Levanger Hospital, Nord-Tr\u00f8ndelag Health Trust, 7600 Levanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Midthjell","sequence":"additional","affiliation":[{"name":"HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-9744","authenticated-orcid":true,"given":"Kristian","family":"Hveem","sequence":"additional","affiliation":[{"name":"HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, 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