{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:05Z","timestamp":1740169745966,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2009\/53946-3"],"award-info":[{"award-number":["2009\/53946-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Iron abnormalities in chronic liver disease may be the result of genetic diseases or secondary factors. The present study aimed to identify subjects with HFE-HH in order to describe the frequency of clinical manifestations, identify risk factors for iron elevation, and compare the iron profile of HFE-HH to other genotypes in liver disease patients. A total of 108 individuals with hepatic disease, transferrin saturation (TS) &gt; 45%, and serum ferritin (SF) &gt; 350\u2009ng\/mL were tested for HFE mutations. Two groups were characterized: C282Y\/C282Y or C282Y\/H63D genotypes (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>16<\/mml:mn><\/mml:math>) were the HFE hereditary hemochromatosis (HFE-HH) group; and C282Y and H63D single heterozygotes, the H63D\/H63D genotype, and wild-type were considered group 2 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>92<\/mml:mn><\/mml:math>). Nonalcoholic liver disease, alcoholism, and chronic hepatitis C were detected more frequently in group 2, whereas arthropathy, hepatocarcinoma, diabetes, and osteoporosis rates were significantly higher in the HFE-HH group. TS &gt; 82%, SF &gt; 2685\u2009ng\/mL, and serum iron &gt; 178\u2009<jats:italic>\u03bc<\/jats:italic>g\/dL were the cutoffs for diagnosis of HFE-HH in patients with liver disease. Thus, in non-Caucasian populations with chronic liver disease, HFE-HH diagnosis is more predictable in those with iron levels higher than those proposed in current guidelines for the general population.<\/jats:p>","DOI":"10.1155\/2015\/164671","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T16:01:17Z","timestamp":1421251277000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver Diseases"],"prefix":"10.1155","volume":"2015","author":[{"given":"Andreia Silva","family":"Evangelista","sequence":"first","affiliation":[{"name":"Department of Gastroenterology from University of Sao Paulo School of Medicine, Avenue Dr Eneas de Carvalho Aguiar 255, 05403-000 Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-768X","authenticated-orcid":true,"given":"Maria 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