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The antioxidant activity in sorghum kafirin extract measured by the DPPH and TEAC methods was increased 30 and 65 times, respectively, compared to that of its counterpart, sorghum flour. According to electrophoresis assay, the kafirins<jats:italic>tert<\/jats:italic>-butanol extract showed a high proportion of<jats:italic>\u03b1<\/jats:italic>-kafirin monomers, and its amino acid composition revealed higher hydrophobic amino acid content such as alanine, isoleucine, leucine, tyrosine and phenylalanine than sorghum flour extract. Diets supplemented with sorghum kafirin extract have improved lipid metabolism and increased the serum antioxidant potential (67%) especially in rats fed with added cholesterol. The bioactive peptides generated from kafirin<jats:italic>in vivo<\/jats:italic>hydrolysis appear to be associated with the positive effect on serum lipids and antioxidant activity. According to these results, sorghum kafirin extract at the levels used in this study apparently could be used for prevention of atherosclerosis and other chronic diseases.<\/jats:p>","DOI":"10.1155\/2015\/164725","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T17:01:06Z","timestamp":1445878866000},"page":"1-8","source":"Crossref","is-referenced-by-count":24,"title":["Influence of Sorghum Kafirin on Serum Lipid Profile and Antioxidant Activity in Hyperlipidemic Rats (<i>In Vitro<\/i>and<i>In Vivo<\/i>Studies)"],"prefix":"10.1155","volume":"2015","author":[{"given":"Raquel A.","family":"Ort\u00edz Cruz","sequence":"first","affiliation":[{"name":"Departamento de Investigaci\u00f3n y Posgrado en Alimentos, Universidad de Sonora, Boulevard Luis Encinas y Rosales, Colonia Centro, 83000 Hermosillo Sonora, SON, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"C\u00e1rdenas L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n y Posgrado en Alimentos, Universidad de Sonora, Boulevard Luis Encinas y Rosales, Colonia Centro, 83000 Hermosillo Sonora, SON, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A.","family":"Gonz\u00e1lez Aguilar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Alimentaci\u00f3n y Desarrollo, A.C. 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