{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:22:39Z","timestamp":1779114159333,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Pharmacological Sciences"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>The present study was designed to evaluate the acute and chronic antidepressant effect of genistein in combination with amitriptyline in mice. Animals were divided into six groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">6<\/mml:mn><\/mml:math>) for treatment with water, genistein, or amitriptyline, either alone or in combination for ten days. Animals were subjected to locomotor activity testing; tail suspension test (TST); and forced swim test (FST) and immobility time was recorded on day one and day ten. Acute treatment of all treatment groups did not significantly reduce the immobility time (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). Chronic treatment of combination of genistein (10\u2009mg\/kg) and amitriptyline (5\u2009mg\/kg and 10\u2009mg\/kg) significantly reduced the immobility time as compared to control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) and was comparable to amitriptyline alone (10\u2009mg\/kg). However, no changes in anti-immobility activity in combination of subeffective doses of genistein (5\u2009mg\/kg) and amitriptyline (5\u2009mg\/kg) were observed. Genistein at its standard dose (10\u2009mg\/kg) rendered synergistic effects in combination with subeffective dose of amitriptyline (5\u2009mg\/kg) and additive effects in combination with therapeutic dose of amitriptyline (10\u2009mg\/kg).<\/jats:p>","DOI":"10.1155\/2015\/164943","type":"journal-article","created":{"date-parts":[[2015,11,22]],"date-time":"2015-11-22T21:01:13Z","timestamp":1448226073000},"page":"1-6","source":"Crossref","is-referenced-by-count":23,"title":["Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study"],"prefix":"10.1155","volume":"2015","author":[{"given":"Gaurav","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Life Science, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia"},{"name":"School of Medicine and Public Health, University of Newcastle, Newcastle, NSW 2308, 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