{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:31:18Z","timestamp":1777537878574,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["480918\/2007-4"],"award-info":[{"award-number":["480918\/2007-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mood and Anxiety Disorders Program","award":["480918\/2007-4"],"award-info":[{"award-number":["480918\/2007-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Introduction\/Objective<\/jats:italic>. Evidence suggests that the prefrontal cortex has been implicated in the pathophysiology of bipolar disorder (BD), but few neurochemical studies have evaluated this region in bipolar patients and there is no information from BD suicide attempters using Proton Magnetic Resonance Spectroscopy (H<jats:sup>+<\/jats:sup>MRS). The objective was to evaluate the metabolic function of the medial orbital frontal cortex in euthymic BD type I suicide and nonsuicide attempters compared to healthy subjects by H<jats:sup>+<\/jats:sup>MRS.<jats:italic>Methods<\/jats:italic>. 40 euthymic bipolar I outpatients, 19 without and 21 with history of suicide attempt, and 22 healthy subjects were interviewed using the Structured Clinical Interview with the DSM-IV axis I, the Hamilton Depression Rating Scale, the Young Mania Rating Scale, and the Barratt Impulsiveness Scale-11 and underwent H<jats:sup>+<\/jats:sup>MRS.<jats:italic>Results<\/jats:italic>. We did not find any metabolic abnormality in medial orbital frontal regions of suicide and nonsuicide BD patients and BD patients as a group compared to healthy subjects.<jats:italic>Conclusions<\/jats:italic>. The combined chronic use of psychotropic drugs with neuroprotective or neurotrophic effects leading to a euthymic state for longer periods of time may improve neurometabolic function, at least measured by H<jats:sup>+<\/jats:sup>MRS, even in suicide attempters. Besides, these results may implicate mood dependent alterations in brain metabolic activity. However, more studies with larger sample sizes of this heterogeneous disorder are warranted to clarify these data.<\/jats:p>","DOI":"10.1155\/2015\/165180","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T17:04:24Z","timestamp":1431536664000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["Normal Metabolic Levels in Prefrontal Cortex in Euthymic Bipolar I Patients with and without Suicide Attempts"],"prefix":"10.1155","volume":"2015","author":[{"given":"Marlos Vasconcelos","family":"Rocha","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Nery-Fernandes","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luiz","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas de Castro","family":"Quarantini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irismar Reis","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna G.","family":"Ladeia-Rocha","sequence":"additional","affiliation":[{"name":"Image Memorial, Medicina Diagn\u00f3stica, Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Parolin","family":"Jackowski","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Interdisciplinar de Neuroci\u00eancias Cl\u00ednicas (LiNC), Universidade Federal de S\u00e3o Paulo, 04021-001 S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"de Araujo Neto","sequence":"additional","affiliation":[{"name":"Image Memorial, Medicina Diagn\u00f3stica, Salvador, BA, Brazil"},{"name":"Department of Radiology, Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c2ngela","family":"Miranda-Scippa","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil"},{"name":"Postgraduate Program in Medicine and Health, Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12087"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.9.1680"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2010.10.026"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.6.720"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5606-03.2004"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-3223(03)00168-9"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.2.304"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.03.027"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/01.nmd.0000180777.41295.65"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.09.006"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s002590000392"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.07.058"},{"issue":"4","key":"13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1017\/S1092852900020770","volume":"11","year":"2006","journal-title":"CNS Spectrums"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2002.02235.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/hup.761"},{"issue":"434","key":"16","first-page":"57","year":"2007","journal-title":"Acta Psychiatrica Scandinavica. 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