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Progress in GAS vaccine development has been hindered by a number of obstacles, including a lack of standardization in immunoassays and the need to define human correlates of protection. In this review, we have examined the current immunoassays used in both GAS and other organisms, and explored the various challenges in their implementation in order to propose potential future directions to identify a correlate of protection and facilitate the development of M protein-based vaccines, which are currently the main GAS vaccine candidates.<\/jats:p>","DOI":"10.1155\/2015\/167089","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T21:03:24Z","timestamp":1432587804000},"page":"1-11","source":"Crossref","is-referenced-by-count":38,"title":["Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9254-6339","authenticated-orcid":true,"given":"Shu Ki","family":"Tsoi","sequence":"first","affiliation":[{"name":"Group A Streptococcus Research Group, Murdoch Childrens Research Institute, Melbourne, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre R.","family":"Smeesters","sequence":"additional","affiliation":[{"name":"Group A Streptococcus Research Group, Murdoch Childrens Research Institute, Melbourne, VIC 3052, Australia"},{"name":"Centre for International Child Health, University of Melbourne, Melbourne, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah R. 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