{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:47:21Z","timestamp":1728175641077},"reference-count":29,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>In this experimental study we have investigated whether the inclusion of the dietary fiber<jats:italic>Plantago ovata<\/jats:italic>husk could be recommended as coadjuvant in treatments with oral hypoglycemic drugs. We evaluated the use of<jats:italic>Plantago ovata<\/jats:italic>husk-metformin association in diabetic rabbits by determining its effects on glucose and insulin concentrations. Six groups of 6 rabbits were used. Groups 1 to 3 were fed with standard chow and groups 4 to 6 with chow supplemented with<jats:italic>Plantago ovata<\/jats:italic>husk (3.5\u2009mg\/kg\/day). Two groups (numbers 1 and 4) were used as controls (receiving standard or supplemented chow), two groups (numbers 2 and 5) received metformin orally, and the other two (numbers 3 and 6) were treated orally with metformin and psyllium. Plasma glucose concentrations were lower in groups fed with fiber-supplemented chow whereas insulin levels showed important interindividual variations. Glucose pharmacokinetics parameters showed significant differences in<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>C<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>max<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>t<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>max<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>in relation to fiber intake. Insulin pharmacokinetics parameters after treatment with oral metformin showed an important increase in<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mi>C<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>max<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>, AUC, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:msub><mml:mrow><mml:mi>t<\/mml:mi><\/mml:mrow><mml:mrow><mml:mtext>max<\/mml:mtext><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>in animals fed with fiber. We conclude that<jats:italic>Plantago ovata<\/jats:italic>husk intake can contribute to the oral antihyperglycemic treatment of type 2 diabetes.<\/jats:p>","DOI":"10.1155\/2015\/167526","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T17:03:56Z","timestamp":1445360636000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the Association Metformin:<i>Plantago ovata<\/i>Husk in Diabetic Rabbits"],"prefix":"10.1155","volume":"2015","author":[{"given":"Raquel","family":"D\u00edez-L\u00e1iz","sequence":"first","affiliation":[{"name":"Pharmacology, Institute of Biomedicine (IBIOMED), University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Garc\u00eda-Vieitez","sequence":"additional","affiliation":[{"name":"Pharmacology, Institute of Biomedicine (IBIOMED), University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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