{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:15:14Z","timestamp":1781885714144,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2009-0077541"],"award-info":[{"award-number":["NRF-2009-0077541"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Lespedeza<\/jats:italic>has been used for the management of diabetes in folklore medicine. The purpose of this study is to investigate the protective effects of the methanol extract of<jats:italic>Lespedeza davurica<\/jats:italic>(LD) on cytokine-induced<jats:italic>\u03b2<\/jats:italic>-cell damage and streptozotocin- (STZ-) induced diabetes. RINm5F cells were treated with interleukin- (IL-) 1<jats:italic>\u03b2<\/jats:italic>and interferon- (IFN-)<jats:italic>\u03b3<\/jats:italic>to induce pancreatic<jats:italic>\u03b2<\/jats:italic>-cell damage. The exposure of LD extract significantly decreased cell death, nitric oxide (NO) production, nitric oxide synthase (iNOS) expression, and nucleus factor-kappa B (NF-<jats:italic>\u03ba<\/jats:italic>B) p65 activation. Antidiabetic effects of LD extract were observed by oral glucose tolerance test (OGTT) in normal rats and by checking the biochemical, physiological, and histopathological parameters in STZ-induced diabetic rats. In OGTT, glucose clearance levels improved by oral treatment of LD extract. The water intake, urine volume, blood glucose, and serum TG, TC, TBARS, and DPP-IV levels were significantly decreased, and liver glycogen content was significantly increased by treatment of LD extract (250\u2009mg\/kg BW) in STZ-induced diabetic rats. Also, insulin immunoreactivity of the pancreases was increased in LD extract administrated rats compared with diabetic control rats. These results indicate that LD extract may protect pancreatic<jats:italic>\u03b2<\/jats:italic>-cell damage and regulate the blood glucose in STZ-induced diabetic rats.<\/jats:p>","DOI":"10.1155\/2015\/169256","type":"journal-article","created":{"date-parts":[[2015,2,22]],"date-time":"2015-02-22T16:00:54Z","timestamp":1424620854000},"page":"1-8","source":"Crossref","is-referenced-by-count":13,"title":["<i>Lespedeza davurica<\/i>(Lax.) Schindl. Extract Protects against Cytokine-Induced<i>\u03b2<\/i>-Cell Damage and Streptozotocin-Induced Diabetes"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3609-833X","authenticated-orcid":true,"given":"Bhesh Raj","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Oriental Medicine Resources and Institute of Korean Medicine Industry, College of Natural Science, Mokpo National University, 1666 Youngsan-ro, Muan-gun, Jeonnam 534-729, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1189-3126","authenticated-orcid":true,"given":"Dong Young","family":"Rhyu","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Resources and Institute of Korean Medicine Industry, College of Natural Science, Mokpo National University, 1666 Youngsan-ro, Muan-gun, Jeonnam 534-729, Republic of Korea"},{"name":"Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199411243312107"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.21"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3109\/10408361003787171"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223545"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1293.017"},{"key":"6","year":"1991"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/162724"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/185676"},{"key":"9","volume":"5","year":"2011"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1080\/10286020600979894"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.5897\/jmpr2014.5485"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/s1875-5364(13)60042-4"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1080\/09553009014552121"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.84243"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.suppl_2.s97"},{"issue":"27","key":"16","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.3748\/wjg.v12.i27.4331","volume":"12","year":"2006","journal-title":"World Journal of Gastroenterology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0886-7"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.7.1000"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.06.001"},{"issue":"7","key":"20","first-page":"1485","volume":"30","year":"2010","journal-title":"Acta Botanica Boreali-Occidentalia Sinica"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmhi.2013.06.001"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/169256.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/169256.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/169256.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T02:02:48Z","timestamp":1498183368000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/169256\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":21,"alternative-id":["169256","169256"],"URL":"https:\/\/doi.org\/10.1155\/2015\/169256","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}